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Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with Guanosine 5' monophosphate

X-ray diffraction
2.73Å resolution
PDB entry 5jv5 coloured by chain, front view.
PDB entry 5jv5 coloured by chain, side view.
PDB entry 5jv5 coloured by chain, top view.
Source organism: Trypanosoma brucei brucei
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hypoxanthine-guanine phosphoribosyltransferase
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Multimeric state: homo dimer
Accessible surface area: 16438.38 Å2
Buried surface area: 5438.21 Å2
Dissociation area: 1,553.01 Å2
Dissociation energy (ΔGdiss): 12.31 kcal/mol
Dissociation entropy (TΔSdiss): 12.84 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-170435

Macromolecules

Hypoxanthine-guanine phosphoribosyltransferase
Chains: A, B
Length: 216 amino acids
Theoretical weight: 24.22 KDa
Source organism: Trypanosoma brucei brucei
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07010 (Residues: 1-210; Coverage: 100%)
Gene name: HGPRT
Pfam: Phosphoribosyl transferase domain
InterPro:
CATH: Rossmann fold
Hypoxanthine-guanine phosphoribosyltransferase in PDB entry 5jv5, assembly 1, front view.
Hypoxanthine-guanine phosphoribosyltransferase in PDB entry 5jv5, assembly 1, side view.
Hypoxanthine-guanine phosphoribosyltransferase in PDB entry 5jv5, assembly 1, top view.
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