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Allosteric inhibition of Kidney Isoform of Glutaminase

X-ray diffraction
2.098Å resolution
PDB entry 5jyo coloured by chain, front view.
PDB entry 5jyo coloured by chain, side view.
PDB entry 5jyo coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo tetramer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glutaminase kidney isoform, mitochondrial 65 kDa chain
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Multimeric state: monomeric
Accessible surface area: 13043.49 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131794
Assembly 10
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Assembly Name: Glutaminase kidney isoform, mitochondrial 65 kDa chain
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Multimeric state: homo tetramer
Accessible surface area: 43711.33 Å2
Buried surface area: 8117.94 Å2
Dissociation area: 1,627.11 Å2
Dissociation energy (ΔGdiss): 3.28 kcal/mol
Dissociation entropy (TΔSdiss): 14.83 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-131797
Assembly 2
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Assembly Name: Glutaminase kidney isoform, mitochondrial 65 kDa chain
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Multimeric state: monomeric
Accessible surface area: 12762.12 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131794
Assembly 3
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Assembly Name: Glutaminase kidney isoform, mitochondrial 65 kDa chain
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Multimeric state: monomeric
Accessible surface area: 12727.66 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131794
Assembly 4
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Assembly Name: Glutaminase kidney isoform, mitochondrial 65 kDa chain
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Multimeric state: monomeric
Accessible surface area: 12900.41 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131794
Assembly 5
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Assembly Name: Glutaminase kidney isoform, mitochondrial 65 kDa chain
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Multimeric state: monomeric
Accessible surface area: 12681.73 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131794
Assembly 6
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Assembly Name: Glutaminase kidney isoform, mitochondrial 65 kDa chain
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Multimeric state: monomeric
Accessible surface area: 13689.09 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131794
Assembly 7
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Assembly Name: Glutaminase kidney isoform, mitochondrial 65 kDa chain
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Multimeric state: monomeric
Accessible surface area: 12622.25 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131794
Assembly 8
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Assembly Name: Glutaminase kidney isoform, mitochondrial 65 kDa chain
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Multimeric state: monomeric
Accessible surface area: 12755.81 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131794
Assembly 9
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Assembly Name: Glutaminase kidney isoform, mitochondrial 65 kDa chain
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Multimeric state: homo tetramer
Accessible surface area: 43997.89 Å2
Buried surface area: 7355.39 Å2
Dissociation area: 1,551.88 Å2
Dissociation energy (ΔGdiss): 3.84 kcal/mol
Dissociation entropy (TΔSdiss): 14.81 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-131797

Macromolecules

Glutaminase kidney isoform, mitochondrial 65 kDa chain
Chains: A, B, C, D, E, F, G, H
Length: 333 amino acids
Theoretical weight: 36.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O94925 (Residues: 221-533; Coverage: 47%)
Gene names: GLS, GLS1, KIAA0838
Pfam: Glutaminase
InterPro:
CATH: DD-peptidase/beta-lactamase superfamily
Glutaminase kidney isoform, mitochondrial 65 kDa chain in PDB entry 5jyo, assembly 1, front view.
Glutaminase kidney isoform, mitochondrial 65 kDa chain in PDB entry 5jyo, assembly 1, side view.
Glutaminase kidney isoform, mitochondrial 65 kDa chain in PDB entry 5jyo, assembly 1, top view.
PDBe-KB: UniProt Coverage View: O94925  
133350100150200250300
 
100200300
UniProt
O94925
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Sequence conservation
Molecule details ›

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