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Crystal structure of WD repeat-containing protein 20

X-ray diffraction
2.602Å resolution
PDB entry 5k19 coloured by chain, front view.
PDB entry 5k19 coloured by chain, side view.
PDB entry 5k19 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: WD repeat-containing protein 20
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Multimeric state: monomeric
Accessible surface area: 15856.06 Å2
Buried surface area: 386.03 Å2
Dissociation area: 129.89 Å2
Dissociation energy (ΔGdiss): 0.86 kcal/mol
Dissociation entropy (TΔSdiss): 0.96 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-186182
Assembly 2
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Assembly Name: WD repeat-containing protein 20
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Multimeric state: monomeric
Accessible surface area: 15911.02 Å2
Buried surface area: 683.41 Å2
Dissociation area: 65.59 Å2
Dissociation energy (ΔGdiss): -1.67 kcal/mol
Dissociation entropy (TΔSdiss): 0.89 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-186182
Assembly 3
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Assembly Name: WD repeat-containing protein 20
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Multimeric state: monomeric
Accessible surface area: 14465.73 Å2
Buried surface area: 236.4 Å2
Dissociation area: 118.2 Å2
Dissociation energy (ΔGdiss): 1.33 kcal/mol
Dissociation entropy (TΔSdiss): 0.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-186182

Macromolecules

WD repeat-containing protein 20
Chains: A, B, C
Length: 569 amino acids
Theoretical weight: 62.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q8TBZ3 (Residues: 1-569; Coverage: 100%)
Gene name: WDR20
Pfam: WD domain, G-beta repeat
InterPro:
CATH: YVTN repeat-like/Quinoprotein amine dehydrogenase
WD repeat-containing protein 20 in PDB entry 5k19, assembly 1, front view.
WD repeat-containing protein 20 in PDB entry 5k19, assembly 1, side view.
WD repeat-containing protein 20 in PDB entry 5k19, assembly 1, top view.
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