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Crystal structure of the complex between human phosphatase PRL-2 in the oxidized state with the Bateman domain of human magnesium transporter CNNM3

X-ray diffraction
2.96Å resolution
PDB entry 5k23 coloured by chain, front view.
PDB entry 5k23 coloured by chain, side view.
PDB entry 5k23 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero tetramer (preferred)
hetero octamer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein tyrosine phosphatase type IVA 2 and Metal transporter CNNM3
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Multimeric state: hetero tetramer
Accessible surface area: 27968.53 Å2
Buried surface area: 5584.65 Å2
Dissociation area: 1,517.26 Å2
Dissociation energy (ΔGdiss): 6.65 kcal/mol
Dissociation entropy (TΔSdiss): 24.61 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-171465
Assembly 2
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Assembly Name: Protein tyrosine phosphatase type IVA 2 and Metal transporter CNNM3
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Multimeric state: hetero octamer
Accessible surface area: 54584.69 Å2
Buried surface area: 12521.68 Å2
Dissociation area: 721.6 Å2
Dissociation energy (ΔGdiss): 0.68 kcal/mol
Dissociation entropy (TΔSdiss): 14.93 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-171466

Macromolecules

Protein tyrosine phosphatase type IVA 2
Chain: A
Length: 189 amino acids
Theoretical weight: 21.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q12974 (Residues: 1-167; Coverage: 100%)
Gene names: BM-008, PRL2, PTP4A2, PTPCAAX2
Pfam: Protein-tyrosine phosphatase
InterPro:
CATH: Protein tyrosine phosphatase superfamily
Protein tyrosine phosphatase type IVA 2 in PDB entry 5k23, assembly 1, front view.
Protein tyrosine phosphatase type IVA 2 in PDB entry 5k23, assembly 1, side view.
Protein tyrosine phosphatase type IVA 2 in PDB entry 5k23, assembly 1, top view.
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Metal transporter CNNM3
Chain: C
Length: 155 amino acids
Theoretical weight: 17.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8NE01 (Residues: 309-452; Coverage: 20%)
Gene names: ACDP3, CNNM3
Pfam: CBS domain
InterPro:
CATH: CBS-domain
Metal transporter CNNM3 in PDB entry 5k23, assembly 1, front view.
Metal transporter CNNM3 in PDB entry 5k23, assembly 1, side view.
Metal transporter CNNM3 in PDB entry 5k23, assembly 1, top view.
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