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AMPK bound to allosteric activator

X-ray diffraction
3.41Å resolution
PDB entry 5kq5 coloured by chain, front view.
PDB entry 5kq5 coloured by chain, side view.
PDB entry 5kq5 coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 5'-AMP-activated protein kinase
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Multimeric state: hetero trimer
Accessible surface area: 35276.37 Å2
Buried surface area: 12227.67 Å2
Dissociation area: 1,422.03 Å2
Dissociation energy (ΔGdiss): 14.4 kcal/mol
Dissociation entropy (TΔSdiss): 13.65 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-157065

Macromolecules

5'-AMP-activated protein kinase catalytic subunit alpha-1
Chain: A
Length: 503 amino acids
Theoretical weight: 57.78 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P54645 (Residues: 11-480, 532-532, 536-559; Coverage: 89%)
Gene names: Ampk1, Prkaa1
Pfam:
InterPro:
5'-AMP-activated protein kinase catalytic subunit alpha-1 in PDB entry 5kq5, assembly 1, front view.
5'-AMP-activated protein kinase catalytic subunit alpha-1 in PDB entry 5kq5, assembly 1, side view.
5'-AMP-activated protein kinase catalytic subunit alpha-1 in PDB entry 5kq5, assembly 1, top view.
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5'-AMP-activated protein kinase subunit beta-1
Chain: B
Length: 204 amino acids
Theoretical weight: 23.05 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P80386 (Residues: 67-270; Coverage: 76%)
Gene name: Prkab1
Pfam:
InterPro:
CATH: Double Stranded RNA Binding Domain
5'-AMP-activated protein kinase subunit beta-1 in PDB entry 5kq5, assembly 1, front view.
5'-AMP-activated protein kinase subunit beta-1 in PDB entry 5kq5, assembly 1, side view.
5'-AMP-activated protein kinase subunit beta-1 in PDB entry 5kq5, assembly 1, top view.
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5'-AMP-activated protein kinase subunit gamma-1
Chain: C
Length: 330 amino acids
Theoretical weight: 37.43 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P80385 (Residues: 1-330; Coverage: 100%)
Gene name: Prkag1
Pfam: CBS domain
InterPro:
5'-AMP-activated protein kinase subunit gamma-1 in PDB entry 5kq5, assembly 1, front view.
5'-AMP-activated protein kinase subunit gamma-1 in PDB entry 5kq5, assembly 1, side view.
5'-AMP-activated protein kinase subunit gamma-1 in PDB entry 5kq5, assembly 1, top view.
Molecule details ›

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