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Crystal structure of Pyrococcus horikoshii quinolinate synthase (NadA) with bound itaconate and Fe4S4 cluster

X-ray diffraction
1.542Å resolution
PDB entry 5ktp coloured by chain, front view.
PDB entry 5ktp coloured by chain, side view.
PDB entry 5ktp coloured by chain, top view.
Source organism: Pyrococcus horikoshii OT3
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Quinolinate synthase
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Multimeric state: monomeric
Accessible surface area: 12546.79 Å2
Buried surface area: 587.65 Å2
Dissociation area: 35.31 Å2
Dissociation energy (ΔGdiss): 1.77 kcal/mol
Dissociation entropy (TΔSdiss): -2.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-129606

Macromolecules

Quinolinate synthase
Chain: A
Length: 304 amino acids
Theoretical weight: 34.58 KDa
Source organism: Pyrococcus horikoshii OT3
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O57767 (Residues: 1-300; Coverage: 100%)
Gene names: PH0013, nadA
Pfam: Quinolinate synthetase A protein
InterPro:
CATH: NadA-like
Quinolinate synthase in PDB entry 5ktp, assembly 1, front view.
Quinolinate synthase in PDB entry 5ktp, assembly 1, side view.
Quinolinate synthase in PDB entry 5ktp, assembly 1, top view.
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