› 5kuo

X-ray diffraction
1.7Å resolution

Human cyclophilin A at 100K, Data set 3

Released:
DOI: 10.2210/pdb5kuo/pdb
PDB entry 5kuo coloured by chain, front view.
PDB entry 5kuo coloured by chain, side view.
PDB entry 5kuo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational variation of proteins at room temperature is not dominated by radiation damage.
Russi S, González A, Kenner LR, Keedy DA, Fraser JS, van den Bedem H
OpenAccess logo J Synchrotron Radiat 24 73-82 (2017)
PMID: 28009548

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-549123 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase A Chain: A
Molecule details ›
Chain: A
Length: 164 amino acids
Theoretical weight: 17.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62937 (Residues: 2-165; Coverage: 99%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P212121
Unit cell:
a: 42.349Å b: 52.585Å c: 89.271Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.175 0.214
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Atomic displacement parameters in structural biology.
Carugo O. (2018)
1 more

1 mention without citation

The In Vitro Interaction of 12-Oxophytodienoic Acid and Related Conjugated Carbonyl Compounds with Thiol Antioxidants.
Maynard et al. (2021)