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Crystal structure of human phosphodiesterase 4B catalytic domain with inhibitor NPD-001

X-ray diffraction
2.4Å resolution
PDB entry 5laq coloured by chain, front view.
PDB entry 5laq coloured by chain, side view.
PDB entry 5laq coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 3',5'-cyclic-AMP phosphodiesterase 4B
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Multimeric state: monomeric
Accessible surface area: 15040.0 Å2
Buried surface area: 855.67 Å2
Dissociation area: 59.98 Å2
Dissociation energy (ΔGdiss): 0.36 kcal/mol
Dissociation entropy (TΔSdiss): -0.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170460

Macromolecules

3',5'-cyclic-AMP phosphodiesterase 4B
Chain: A
Length: 421 amino acids
Theoretical weight: 48.44 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q07343 (Residues: 241-289, 305-659; Coverage: 55%)
Gene names: DPDE4, PDE4B
Pfam:
InterPro:
CATH: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
3',5'-cyclic-AMP phosphodiesterase 4B in PDB entry 5laq, assembly 1, front view.
3',5'-cyclic-AMP phosphodiesterase 4B in PDB entry 5laq, assembly 1, side view.
3',5'-cyclic-AMP phosphodiesterase 4B in PDB entry 5laq, assembly 1, top view.
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