Structure analysis

Domain-swapped dimer of human Dishevelled2 DEP domain: monoclinic crystal form crystallised from monomeric fraction

X-ray diffraction
1.99Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero tetramer
Accessible surface area: 21481.75 Å2
Buried surface area: 11967.53 Å2
Dissociation area: 714.53 Å2
Dissociation energy (ΔGdiss): -17.48 kcal/mol
Dissociation entropy (TΔSdiss): 12.28 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-127032

Macromolecules

Chains: A, C, D
Length: 97 amino acids
Theoretical weight: 10.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14641 (Residues: 416-510; Coverage: 13%)
Gene name: DVL2
Pfam: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
InterPro:

Search similar proteins

Chain: B
Length: 97 amino acids
Theoretical weight: 10.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14641 (Residues: 416-510; Coverage: 13%)
Gene name: DVL2
Pfam: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
InterPro:

Search similar proteins