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Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1

Source organisms:
Biochemical function: maltose binding
Biological process: transmembrane transport
Cellular component: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00452
Domain description: Apoptosis regulator proteins, Bcl-2 family
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein
The deposited structure of PDB entry 5lof contains 1 copy of Pfam domain PF00452 (Apoptosis regulator proteins, Bcl-2 family) in Induced myeloid leukemia cell differentiation protein Mcl-1. Showing 1 copy in chain A.

PF01547
Domain description: Bacterial extracellular solute-binding protein
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein
The deposited structure of PDB entry 5lof contains 1 copy of Pfam domain PF01547 (Bacterial extracellular solute-binding protein) in Induced myeloid leukemia cell differentiation protein Mcl-1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006060
Domain description: Maltose/Cyclodextrin ABC transporter, substrate-binding protein
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein
IPR036834
Domain description: Bcl-2-like superfamily
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein
IPR020726
Domain description: Apoptosis regulator, Bcl-2, BH2 motif, conserved site
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein
IPR020717
Domain description: Apoptosis regulator, Bcl-2, BH1 motif, conserved site
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein
IPR046371
Domain description: Bcl-2, Bcl-2 homology region 1-3
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein
IPR002475
Domain description: Bcl2-like
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein
IPR020728
Domain description: Apoptosis regulator, Bcl-2, BH3 motif, conserved site
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein
IPR026298
Domain description: Bcl-2 family
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein
IPR006061
Domain description: Solute-binding family 1, conserved site
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein
IPR006059
Domain description: Bacterial-type extracellular solute-binding protein
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein

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