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Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1

X-ray diffraction
2.2Å resolution
PDB entry 5lof coloured by chain, front view.
PDB entry 5lof coloured by chain, side view.
PDB entry 5lof coloured by chain, top view.
Source organisms:
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Induced myeloid leukemia cell differentiation protein Mcl-1, Maltose/maltodextrin-binding periplasmic protein
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Multimeric state: monomeric
Accessible surface area: 21702.95 Å2
Buried surface area: 825.37 Å2
Dissociation area: 350.4 Å2
Dissociation energy (ΔGdiss): -4.28 kcal/mol
Dissociation entropy (TΔSdiss): 4.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-142652

Macromolecules

Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein
Chain: A
Length: 518 amino acids
Theoretical weight: 57.23 KDa
Source organisms: Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P0AEY0 (Residues: 27-392; Coverage: 99%)
  • Canonical: Q07820 (Residues: 173-321; Coverage: 43%)
    • nullnull
Gene names: BCL2L3, ECs5017, MCL1, Z5632, malE
Pfam:
InterPro:
Induced myeloid leukemia cell differentiation protein Mcl-1 in PDB entry 5lof, assembly 1, front view.
Induced myeloid leukemia cell differentiation protein Mcl-1 in PDB entry 5lof, assembly 1, side view.
Induced myeloid leukemia cell differentiation protein Mcl-1 in PDB entry 5lof, assembly 1, top view.
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