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N-terminal domain of the human tumor suppressor ING5

X-ray diffraction
3.2Å resolution
PDB entry 5me8 coloured by chain, front view.
PDB entry 5me8 coloured by chain, side view.
PDB entry 5me8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Inhibitor of growth protein 5
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Multimeric state: homo dimer
Accessible surface area: 14042.43 Å2
Buried surface area: 3472.1 Å2
Dissociation area: 1,096.07 Å2
Dissociation energy (ΔGdiss): -5.2 kcal/mol
Dissociation entropy (TΔSdiss): 11.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-186799

Macromolecules

Inhibitor of growth protein 5
Chains: A, B
Length: 107 amino acids
Theoretical weight: 12.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8WYH8 (Residues: 1-105; Coverage: 44%)
Gene name: ING5
Pfam: Inhibitor of growth proteins N-terminal histone-binding
InterPro:
Inhibitor of growth protein 5 in PDB entry 5me8, assembly 1, front view.
Inhibitor of growth protein 5 in PDB entry 5me8, assembly 1, side view.
Inhibitor of growth protein 5 in PDB entry 5me8, assembly 1, top view.
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