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D-2-hydroxyacid dehydrogenases (D2-HDH) from Haloferax mediterranei in complex with 2-ketohexanoic acid and NAD+ (1.35 A resolution)

X-ray diffraction
1.35Å resolution
PDB entry 5mh6 coloured by chain, front view.
PDB entry 5mh6 coloured by chain, side view.
PDB entry 5mh6 coloured by chain, top view.
Source organism: Haloferax mediterranei ATCC 33500
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: D-2-hydroxyacid dehydrogenase
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Multimeric state: homo dimer
Accessible surface area: 23359.83 Å2
Buried surface area: 11762.27 Å2
Dissociation area: 2,944.98 Å2
Dissociation energy (ΔGdiss): 24.43 kcal/mol
Dissociation entropy (TΔSdiss): 14.17 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-174099
Assembly 2 (preferred)
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Assembly Name: D-2-hydroxyacid dehydrogenase
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Multimeric state: homo dimer
Accessible surface area: 23304.26 Å2
Buried surface area: 11378.01 Å2
Dissociation area: 2,920.26 Å2
Dissociation energy (ΔGdiss): 22.84 kcal/mol
Dissociation entropy (TΔSdiss): 14.18 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-174099

Macromolecules

D-2-hydroxyacid dehydrogenase
Chains: A, B, C, D
Length: 308 amino acids
Theoretical weight: 33.37 KDa
Source organism: Haloferax mediterranei ATCC 33500
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q2VEQ7 (Residues: 1-308; Coverage: 100%)
Gene names: HFX_2024, ddh, serA5
Pfam: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
InterPro:
D-2-hydroxyacid dehydrogenase in PDB entry 5mh6, assembly 2, front view.
D-2-hydroxyacid dehydrogenase in PDB entry 5mh6, assembly 2, side view.
D-2-hydroxyacid dehydrogenase in PDB entry 5mh6, assembly 2, top view.
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