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[2Fe-2S] cluster containing TtuA in complex with AMP.

Source organism: Pyrococcus horikoshii OT3
Biochemical function: 4 iron, 4 sulfur cluster binding
Biological process: tRNA thio-modification
Cellular component: cytosolic tRNA wobble base thiouridylase complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF01171
Domain description: PP-loop family
Occurring in:
  1. tRNA-5-methyluridine(54) 2-sulfurtransferase
The deposited structure of PDB entry 5mko contains 2 copies of Pfam domain PF01171 (PP-loop family) in tRNA-5-methyluridine(54) 2-sulfurtransferase. Showing 1 copy in chain A.

PF22082
Domain description: 2-thiouridine synthetase TtuA, N-terminal LIM domain
Occurring in:
  1. tRNA-5-methyluridine(54) 2-sulfurtransferase

InterPro InterPro annotations
IPR000541
Domain description: Cytoplasmic tRNA 2-thiolation protein 1
Occurring in:
  1. tRNA-5-methyluridine(54) 2-sulfurtransferase
IPR011063
Domain description: tRNA(Ile)-lysidine/2-thiocytidine synthase, N-terminal
Occurring in:
  1. tRNA-5-methyluridine(54) 2-sulfurtransferase
IPR001763
Domain description: Rhodanese-like domain
Occurring in:
  1. tRNA-5-methyluridine(54) 2-sulfurtransferase
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. tRNA-5-methyluridine(54) 2-sulfurtransferase
IPR035107
Domain description: tRNA thiolation protein, TtcA/Ctu1 type
Occurring in:
  1. tRNA-5-methyluridine(54) 2-sulfurtransferase

Structure domain

CATH CATH domain
3.40.50.620
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HUPs
Occurring in:
  1. tRNA-5-methyluridine(54) 2-sulfurtransferase
The deposited structure of PDB entry 5mko contains 2 copies of CATH domain 3.40.50.620 (Rossmann fold) in tRNA-5-methyluridine(54) 2-sulfurtransferase. Showing 1 copy in chain A.

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