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Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with human Abeta-pE3-12PEGb

X-ray diffraction
2.211Å resolution
PDB entry 5my4 coloured by chain, front view.
PDB entry 5my4 coloured by chain, side view.
PDB entry 5my4 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Soluble APP-beta and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero trimer
Accessible surface area: 19776.95 Å2
Buried surface area: 4608.53 Å2
Dissociation area: 620.03 Å2
Dissociation energy (ΔGdiss): 5.54 kcal/mol
Dissociation entropy (TΔSdiss): 6.48 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-209167

Macromolecules

Fab c#17 light chain
Chain: A
Length: 219 amino acids
Theoretical weight: 24.08 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:
CATH: Immunoglobulins
Fab c#17 light chain in PDB entry 5my4, assembly 1, front view.
Fab c#17 light chain in PDB entry 5my4, assembly 1, side view.
Fab c#17 light chain in PDB entry 5my4, assembly 1, top view.
121920406080100120140160180200
 
100200DVVMTQTPLSLPVSLGDQASISCRSSQSLVHSDGNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVPPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC
Chains
RSRZ Outlier Chain A (auth A)
Chain A (auth A)
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Interaction interfaces
Sequence conservation
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Fab c#17 heavy chain
Chain: B
Length: 231 amino acids
Theoretical weight: 24.65 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:
CATH: Immunoglobulins
Fab c#17 heavy chain in PDB entry 5my4, assembly 1, front view.
Fab c#17 heavy chain in PDB entry 5my4, assembly 1, side view.
Fab c#17 heavy chain in PDB entry 5my4, assembly 1, top view.
123120406080100120140160180200220
 
100200EVKLVESGGGLVQPGGSRKLSCAASGFTFSDYGMAWVRQAPGKGPEWVAFISNLAYSIYYADTVTGRFTISRENAKNTLYLEMSSLRSEDTAMYYCARYDYDNILDYVMDYWGQGTSVTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPC
Chains
RSRZ Outlier Chain B (auth B)
Chain B (auth B)
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Interaction interfaces
Sequence conservation
Molecule details ›

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Amyloid-beta protein 40
Chain: C
Length: 10 amino acids
Theoretical weight: 1.22 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 674-683; Coverage: 1%)
Gene names: A4, AD1, APP
Amyloid-beta protein 40 in PDB entry 5my4, assembly 1, front view.
Amyloid-beta protein 40 in PDB entry 5my4, assembly 1, side view.
Amyloid-beta protein 40 in PDB entry 5my4, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P05067  
11012345678910
 
510*FRHDSGYEV
UniProt
P05067
PRO_0000000091
PRO_0000000093
PRO_0000000088
PRO_0000000089
PRO_0000000092
Chains
Secondary structure
Flexibility predictions
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