Structure analysis

Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with human Abeta-pE3-12PEGb

X-ray diffraction
2.211Å resolution
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 19776.95 Å2
Buried surface area: 4608.53 Å2
Dissociation area: 620.03 Å2
Dissociation energy (ΔGdiss): 5.54 kcal/mol
Dissociation entropy (TΔSdiss): 6.48 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-209167

Macromolecules

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Chain: B
Length: 231 amino acids
Theoretical weight: 24.65 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:
CATH: Immunoglobulins

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Chain: C
Length: 10 amino acids
Theoretical weight: 1.22 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 674-683; Coverage: 1%)
Gene names: A4, AD1, APP

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