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Localised reconstruction of alpha v beta 6 bound to Foot and Mouth Disease Virus O PanAsia - Pose A.

Electron Microscopy
10.8Å resolution
PDB entry 5nem coloured by chain, front view.
PDB entry 5nem coloured by chain, side view.
PDB entry 5nem coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Integrin alphav-beta6 complex
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Multimeric state: hetero hexamer
Accessible surface area: 75105.7 Å2
Buried surface area: 27807.65 Å2
Dissociation area: 2,351.89 Å2
Dissociation energy (ΔGdiss): 12.06 kcal/mol
Dissociation entropy (TΔSdiss): 15.92 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-108159

Macromolecules

Viral protein 1 (VP1)
Chain: 1
Length: 210 amino acids
Theoretical weight: 23.24 KDa
Source organism: Foot-and-mouth disease virus O
Expression system: Cricetinae gen. sp.
UniProt:
  • Canonical: Q98W00 (Residues: 1-210; Coverage: 99%)
Gene name: 1D
Pfam: Picornavirus coat protein
InterPro:
Viral protein 1 (VP1) in PDB entry 5nem, assembly 1, front view.
Viral protein 1 (VP1) in PDB entry 5nem, assembly 1, side view.
Viral protein 1 (VP1) in PDB entry 5nem, assembly 1, top view.
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O PanAsia VP2
Chain: 2
Length: 214 amino acids
Theoretical weight: 23.91 KDa
Source organism: Foot-and-mouth disease virus O
Expression system: Cricetinae gen. sp.
UniProt:
  • Canonical: Q6ZZ87 (Residues: 291-504; Coverage: 9%)
Gene name: polyprotein
Pfam: picornavirus capsid protein
InterPro:
O PanAsia VP2 in PDB entry 5nem, assembly 1, front view.
O PanAsia VP2 in PDB entry 5nem, assembly 1, side view.
O PanAsia VP2 in PDB entry 5nem, assembly 1, top view.
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O PanAsia VP3
Chain: 3
Length: 220 amino acids
Theoretical weight: 23.94 KDa
Source organism: Foot-and-mouth disease virus O
Expression system: Cricetinae gen. sp.
UniProt:
  • Canonical: Q6ZZ87 (Residues: 505-724; Coverage: 9%)
Gene name: polyprotein
Pfam: picornavirus capsid protein
InterPro:
O PanAsia VP3 in PDB entry 5nem, assembly 1, front view.
O PanAsia VP3 in PDB entry 5nem, assembly 1, side view.
O PanAsia VP3 in PDB entry 5nem, assembly 1, top view.
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O PanAsia VP4
Chain: 4
Length: 70 amino acids
Theoretical weight: 7.52 KDa
Source organism: Foot-and-mouth disease virus O
Expression system: Cricetinae gen. sp.
UniProt:
  • Canonical: A6Y878 (Residues: 218-287; Coverage: 3%)
Pfam: Viral protein VP4 subunit
InterPro:
O PanAsia VP4 in PDB entry 5nem, assembly 1, front view.
O PanAsia VP4 in PDB entry 5nem, assembly 1, side view.
O PanAsia VP4 in PDB entry 5nem, assembly 1, top view.
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Integrin alpha-V heavy chain
Chain: A
Length: 590 amino acids
Theoretical weight: 64.94 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P06756 (Residues: 31-624; Coverage: 58%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Pfam:
InterPro:
Integrin alpha-V heavy chain in PDB entry 5nem, assembly 1, front view.
Integrin alpha-V heavy chain in PDB entry 5nem, assembly 1, side view.
Integrin alpha-V heavy chain in PDB entry 5nem, assembly 1, top view.
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Integrin beta-6
Chain: B
Length: 470 amino acids
Theoretical weight: 51.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P18564 (Residues: 22-491; Coverage: 61%)
Gene name: ITGB6
Pfam:
InterPro:
Integrin beta-6 in PDB entry 5nem, assembly 1, front view.
Integrin beta-6 in PDB entry 5nem, assembly 1, side view.
Integrin beta-6 in PDB entry 5nem, assembly 1, top view.
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