5net

Electron Microscopy
8.6Å resolution

Localised Reconstruction of Integrin alpha V beta 6 bound to Foot and Mouth Disease Virus O1 Manisa - Pose A.

Released:

Function and Biology Details

Reactions catalysed:
Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|-Arg- and -Lys-|-Arg-.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-112302 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (10 distinct):
O1 Manisa VP1 Chain: 1
Molecule details ›
Chain: 1
Length: 208 amino acids
Theoretical weight: 22.85 KDa
Source organism: Foot-and-mouth disease virus
Expression system: Cricetinae gen. sp.
UniProt:
  • Canonical: Q6PMW3 (Residues: 725-932; Coverage: 9%)
Sequence domains: Picornavirus coat protein
O1 Manisa VP2 Chain: 2
Molecule details ›
Chain: 2
Length: 218 amino acids
Theoretical weight: 24.42 KDa
Source organism: Foot-and-mouth disease virus
Expression system: Cricetinae gen. sp.
UniProt:
  • Canonical: D1H101 (Residues: 287-504; Coverage: 19%)
Sequence domains: picornavirus capsid protein
O1 Manisa VP3 Chain: 3
O1 Manisa VP4 Chain: 4
Integrin alpha-V heavy chain Chain: A
Integrin beta-6 Chain: B

Ligands and Environments

Carbohydrate polymer : NEW Components: MAN, NAG
Carbohydrate polymer : NEW Components: MAN
Carbohydrate polymer : NEW Components: MAN, NAG
Carbohydrate polymer : NEW Components: MAN, NAG
3 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 8.6Å
Relevant EMDB volumes: EMD-3634
Expression systems:
  • Cricetinae gen. sp.
  • Homo sapiens