› › Structure analysis

Localised Reconstruction of Integrin alpha V beta 6 bound to Foot and Mouth Disease Virus O1 Manisa - Pose A.

Electron Microscopy
8.6Å resolution
PDB entry 5net coloured by chain, front view.
PDB entry 5net coloured by chain, side view.
PDB entry 5net coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 6 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Integrin alphav-beta6 complex
hide full assembly name
Multimeric state: hetero hexamer
Accessible surface area: 75957.14 Å2
Buried surface area: 26877.01 Å2
Dissociation area: 2,148.68 Å2
Dissociation energy (ΔGdiss): 13.66 kcal/mol
Dissociation entropy (TΔSdiss): 15.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-112302

Macromolecules

O1 Manisa VP1
Chain: 1
Length: 208 amino acids
Theoretical weight: 22.85 KDa
Source organism: Foot-and-mouth disease virus
Expression system: Cricetinae gen. sp.
UniProt:
  • Canonical: Q6PMW3 (Residues: 725-932; Coverage: 9%)
Pfam: Picornavirus coat protein
InterPro:
O1 Manisa VP1 in PDB entry 5net, assembly 1, front view.
O1 Manisa VP1 in PDB entry 5net, assembly 1, side view.
O1 Manisa VP1 in PDB entry 5net, assembly 1, top view.
Molecule details ›

Search similar proteins

O1 Manisa VP2
Chain: 2
Length: 218 amino acids
Theoretical weight: 24.42 KDa
Source organism: Foot-and-mouth disease virus
Expression system: Cricetinae gen. sp.
UniProt:
  • Canonical: D1H101 (Residues: 287-504; Coverage: 19%)
Pfam: picornavirus capsid protein
InterPro:
O1 Manisa VP2 in PDB entry 5net, assembly 1, front view.
O1 Manisa VP2 in PDB entry 5net, assembly 1, side view.
O1 Manisa VP2 in PDB entry 5net, assembly 1, top view.
Molecule details ›

Search similar proteins

O1 Manisa VP3
Chain: 3
Length: 220 amino acids
Theoretical weight: 23.95 KDa
Source organism: Foot-and-mouth disease virus
Expression system: Cricetinae gen. sp.
UniProt:
  • Canonical: Q6PMW3 (Residues: 505-724; Coverage: 9%)
Pfam: picornavirus capsid protein
InterPro:
O1 Manisa VP3 in PDB entry 5net, assembly 1, front view.
O1 Manisa VP3 in PDB entry 5net, assembly 1, side view.
O1 Manisa VP3 in PDB entry 5net, assembly 1, top view.
Molecule details ›

Search similar proteins

O1 Manisa VP4
Chain: 4
Length: 85 amino acids
Theoretical weight: 8.77 KDa
Source organism: Foot-and-mouth disease virus
Expression system: Cricetinae gen. sp.
UniProt:
  • Canonical: D1H101 (Residues: 202-286; Coverage: 7%)
Pfam: Viral protein VP4 subunit
InterPro:
O1 Manisa VP4 in PDB entry 5net, assembly 1, front view.
O1 Manisa VP4 in PDB entry 5net, assembly 1, side view.
O1 Manisa VP4 in PDB entry 5net, assembly 1, top view.
Molecule details ›

Search similar proteins

Integrin alpha-V heavy chain
Chain: A
Length: 594 amino acids
Theoretical weight: 65.35 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P06756 (Residues: 31-624; Coverage: 58%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Pfam:
InterPro:
Integrin alpha-V heavy chain in PDB entry 5net, assembly 1, front view.
Integrin alpha-V heavy chain in PDB entry 5net, assembly 1, side view.
Integrin alpha-V heavy chain in PDB entry 5net, assembly 1, top view.
Molecule details ›

Search similar proteins

Integrin beta-6
Chain: B
Length: 470 amino acids
Theoretical weight: 51.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P18564 (Residues: 22-491; Coverage: 61%)
Gene name: ITGB6
Pfam:
InterPro:
Integrin beta-6 in PDB entry 5net, assembly 1, front view.
Integrin beta-6 in PDB entry 5net, assembly 1, side view.
Integrin beta-6 in PDB entry 5net, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links