› 5nsq

X-ray diffraction
3Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-558714 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytosol aminopeptidase domain-containing protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 521 amino acids
Theoretical weight: 55.43 KDa
Source organism: Trypanosoma brucei brucei TREU927
Expression system: Escherichia coli
UniProt:
  • Canonical: Q385B0 (Residues: 1-521; Coverage: 100%)
Gene name: Tb11.02.4440
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MN 12 x MN
Ligand BB2 6 x BB2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 95.909Å b: 165.73Å c: 121.98Å
α: 90° β: 112.45° γ: 90°
R-values:
R R work R free
0.266 0.265 0.296
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids.
Marchese et al. (2018)
4 other articles

2 mentions without citation

Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families.
Pascual Alonso et al. (2023)
1 more