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Structure of Leucyl aminopeptidase from Trypanosoma brucei in complex with Actinonin

X-ray diffraction
3Å resolution
PDB entry 5nsq coloured by chain, front view.
PDB entry 5nsq coloured by chain, side view.
PDB entry 5nsq coloured by chain, top view.
Source organism: Trypanosoma brucei brucei TREU927
Assembly composition:
homo hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cytosol aminopeptidase domain-containing protein
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Multimeric state: homo hexamer
Accessible surface area: 91324.67 Å2
Buried surface area: 33718.4 Å2
Dissociation area: 8,921.91 Å2
Dissociation energy (ΔGdiss): 102.39 kcal/mol
Dissociation entropy (TΔSdiss): 33.86 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-558714

Macromolecules

Cytosol aminopeptidase domain-containing protein
Chains: A, B, C, D, E, F
Length: 521 amino acids
Theoretical weight: 55.43 KDa
Source organism: Trypanosoma brucei brucei TREU927
Expression system: Escherichia coli
UniProt:
  • Canonical: Q385B0 (Residues: 1-521; Coverage: 100%)
Gene name: Tb11.02.4440
Pfam:
InterPro:
CATH:
Cytosol aminopeptidase domain-containing protein in PDB entry 5nsq, assembly 1, front view.
Cytosol aminopeptidase domain-containing protein in PDB entry 5nsq, assembly 1, side view.
Cytosol aminopeptidase domain-containing protein in PDB entry 5nsq, assembly 1, top view.
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