Structure analysis

Structure of the A2A-StaR2-bRIL562-Tozadenant complex at 3.1A obtained from in meso soaking experiments.

X-ray diffraction
3.1Å resolution
Source organisms:
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 20549.32 Å2
Buried surface area: 6538.76 Å2
Dissociation area: 183.75 Å2
Dissociation energy (ΔGdiss): -7.34 kcal/mol
Dissociation entropy (TΔSdiss): 2.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-142061

Macromolecules

Chain: A
Length: 434 amino acids
Theoretical weight: 48.07 KDa
Source organisms: Expression system: Trichoplusia ni
UniProt:
  • Canonical: P29274 (Residues: 2-208, 219-318; Coverage: 75%)
  • Canonical: P0ABE7 (Residues: 23-127; Coverage: 99%)
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Gene names: ADORA2, ADORA2A, cybC
Pfam:
InterPro:

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