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Structure of the apo form of Mycobacterium smegmatis MabA

Source organism: Mycolicibacterium smegmatis MC2 155
Biochemical function: NADP binding
Biological process: monocarboxylic acid metabolic process
Cellular component: extracellular region

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EC 1.1.1.36: Acetoacetyl-CoA reductase

Reaction catalysed:
(R)-3-hydroxyacyl-CoA + NADP(+) = 3-oxoacyl-CoA + NADPH
Systematic name:
(R)-3-hydroxyacyl-CoA:NADP(+) oxidoreductase
Alternative Name(s):
  • (R)-3-hydroxyacyl-CoA dehydrogenase
  • Acetoacetyl coenzyme A reductase
  • Beta-ketoacyl-CoA reductase
  • D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase
  • D-3-hydroxyacyl-CoA reductase
  • Hydroxyacyl coenzyme-A dehydrogenase
  • NADP-linked acetoacetyl CoA reductase
  • NADPH:acetoacetyl-CoA reductase
  • Short chain beta-ketoacetyl(acetoacetyl)-CoA reductase

EC 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase

Reaction catalysed:
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH
Systematic name:
(3R)-3-hydroxyacyl-[acyl-carrier-protein]:NADP(+) oxidoreductase
Alternative Name(s):
  • 3-ketoacyl acyl carrier protein reductase
  • 3-oxoacyl-[ACP]reductase
  • Beta-ketoacyl acyl carrier protein (ACP) reductase
  • Beta-ketoacyl reductase
  • Beta-ketoacyl thioester reductase
  • Beta-ketoacyl-ACP reductase
  • Beta-ketoacyl-[acyl-carrier protein](ACP) reductase
  • Beta-ketoacyl-acyl carrier protein reductase
  • NADPH-specific 3-oxoacyl-[acylcarrier protein]reductase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF13561
Domain description: Enoyl-(Acyl carrier protein) reductase
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] reductase MabA
The deposited structure of PDB entry 5ovj contains 2 copies of Pfam domain PF13561 (Enoyl-(Acyl carrier protein) reductase) in 3-oxoacyl-[acyl-carrier-protein] reductase MabA. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002347
Domain description: Short-chain dehydrogenase/reductase SDR
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] reductase MabA
IPR020904
Domain description: Short-chain dehydrogenase/reductase, conserved site
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] reductase MabA
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] reductase MabA

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] reductase MabA
The deposited structure of PDB entry 5ovj contains 2 copies of CATH domain 3.40.50.720 (Rossmann fold) in 3-oxoacyl-[acyl-carrier-protein] reductase MabA. Showing 1 copy in chain A.

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