Structure analysis

PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N10982a

X-ray diffraction
1.578Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1
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Multimeric state: monomeric
Accessible surface area: 7494.24 Å2
Buried surface area: 395.78 Å2
Dissociation area: 112.62 Å2
Dissociation energy (ΔGdiss): -3.9 kcal/mol
Dissociation entropy (TΔSdiss): -0.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131987
Assembly 2 (preferred)
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Multimeric state: monomeric
Accessible surface area: 7514.33 Å2
Buried surface area: 518.44 Å2
Dissociation area: 93.68 Å2
Dissociation energy (ΔGdiss): -3.28 kcal/mol
Dissociation entropy (TΔSdiss): -0.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131987

Macromolecules

Chains: A, B
Length: 156 amino acids
Theoretical weight: 18.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95696 (Residues: 555-688; Coverage: 13%)
Gene names: BRD1, BRL, BRPF2
Pfam: Bromodomain
InterPro:
CATH: Bromodomain-like

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