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INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z32014663

X-ray diffraction
1.4Å resolution
PDB entry 5rxy coloured by chain, front view.
PDB entry 5rxy coloured by chain, side view.
PDB entry 5rxy coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
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Multimeric state: monomeric
Accessible surface area: 20186.32 Å2
Buried surface area: 803.5 Å2
Dissociation area: 270.86 Å2
Dissociation energy (ΔGdiss): -6.76 kcal/mol
Dissociation entropy (TΔSdiss): 2.79 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187774

Macromolecules

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Chain: A
Length: 463 amino acids
Theoretical weight: 52.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q92835 (Residues: 397-857; Coverage: 39%)
Gene names: INPP5D, SHIP, SHIP1
Pfam: Endonuclease/Exonuclease/phosphatase family 2
InterPro:
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 in PDB entry 5rxy, assembly 1, front view.
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 in PDB entry 5rxy, assembly 1, side view.
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 in PDB entry 5rxy, assembly 1, top view.
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