› › Structure analysis

DDR1, N-[[2-(2-pyridin-3-yloxyethyl)cyclohexyl]methyl]-3-(trifluoromethoxy)benzamide, 1.970A, P212121, Rfree=25.6%

X-ray diffraction
1.97Å resolution
PDB entry 5sb0 coloured by chain, front view.
PDB entry 5sb0 coloured by chain, side view.
PDB entry 5sb0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Epithelial discoidin domain-containing receptor 1
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Multimeric state: monomeric
Accessible surface area: 14534.93 Å2
Buried surface area: 306.52 Å2
Dissociation area: 65.38 Å2
Dissociation energy (ΔGdiss): -0.93 kcal/mol
Dissociation entropy (TΔSdiss): 1.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170636

Macromolecules

Epithelial discoidin domain-containing receptor 1
Chain: A
Length: 321 amino acids
Theoretical weight: 36.5 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q08345 (Residues: 593-913; Coverage: 35%)
Gene names: CAK, DDR1, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
Epithelial discoidin domain-containing receptor 1 in PDB entry 5sb0, assembly 1, front view.
Epithelial discoidin domain-containing receptor 1 in PDB entry 5sb0, assembly 1, side view.
Epithelial discoidin domain-containing receptor 1 in PDB entry 5sb0, assembly 1, top view.
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