Assemblies
Assembly Name:
Proteasome complex
Multimeric state:
hetero 32-mer
Accessible surface area:
442443.32 Å2
Buried surface area:
145739.79 Å2
Dissociation area:
624.06
Å2
Dissociation energy (ΔGdiss):
-15.16
kcal/mol
Dissociation entropy (TΔSdiss):
16.65
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-126174
Macromolecules
Chain: G
Length: 245 amino acids
Theoretical weight: 27.3 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 245 amino acids
Theoretical weight: 27.3 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P60900 (Residues: 2-246; Coverage: 100%)
Pfam:
InterPro:
Chain: H
Length: 233 amino acids
Theoretical weight: 25.8 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 233 amino acids
Theoretical weight: 25.8 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P25787 (Residues: 2-234; Coverage: 100%)
Pfam:
InterPro:
Chain: I
Length: 260 amino acids
Theoretical weight: 29.39 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 260 amino acids
Theoretical weight: 29.39 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P25789 (Residues: 2-261; Coverage: 100%)
Pfam:
InterPro:
Chain: J
Length: 247 amino acids
Theoretical weight: 27.8 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 247 amino acids
Theoretical weight: 27.8 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
O14818 (Residues: 2-248; Coverage: 100%)
Pfam:
InterPro:
Chain: K
Length: 240 amino acids
Theoretical weight: 26.3 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 240 amino acids
Theoretical weight: 26.3 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P28066 (Residues: 2-241; Coverage: 100%)
Pfam:
InterPro:
Chain: M
Length: 254 amino acids
Theoretical weight: 28.34 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 254 amino acids
Theoretical weight: 28.34 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P25788 (Residues: 2-255; Coverage: 100%)
Pfam:
InterPro:
Chain: N
Length: 238 amino acids
Theoretical weight: 25.25 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Proteasome subunit
InterPro:
Length: 238 amino acids
Theoretical weight: 25.25 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P28072 (Residues: 2-239; Coverage: 100%)
Pfam: Proteasome subunit
InterPro:
Chain: O
Length: 276 amino acids
Theoretical weight: 29.87 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 276 amino acids
Theoretical weight: 29.87 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q99436 (Residues: 2-277; Coverage: 100%)
Pfam:
InterPro:
Chain: P
Length: 204 amino acids
Theoretical weight: 22.84 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Proteasome subunit
InterPro:
Length: 204 amino acids
Theoretical weight: 22.84 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P49720 (Residues: 2-205; Coverage: 100%)
Pfam: Proteasome subunit
InterPro:
Chain: Q
Length: 201 amino acids
Theoretical weight: 22.86 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Proteasome subunit
InterPro:
Length: 201 amino acids
Theoretical weight: 22.86 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P49721 (Residues: 1-201; Coverage: 100%)
Pfam: Proteasome subunit
InterPro:
Chain: R
Length: 262 amino acids
Theoretical weight: 28.38 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Proteasome subunit
InterPro:
Length: 262 amino acids
Theoretical weight: 28.38 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P28074 (Residues: 2-263; Coverage: 100%)
Pfam: Proteasome subunit
InterPro:
Chain: S
Length: 240 amino acids
Theoretical weight: 26.39 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Proteasome subunit
InterPro:
Length: 240 amino acids
Theoretical weight: 26.39 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P20618 (Residues: 2-241; Coverage: 100%)
Pfam: Proteasome subunit
InterPro:
Chain: T
Length: 263 amino acids
Theoretical weight: 29.1 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Proteasome subunit
InterPro:
Length: 263 amino acids
Theoretical weight: 29.1 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P28070 (Residues: 2-264; Coverage: 100%)
Pfam: Proteasome subunit
InterPro:
Chain: A
Length: 433 amino acids
Theoretical weight: 48.7 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
Length: 433 amino acids
Theoretical weight: 48.7 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P35998 (Residues: 1-433; Coverage: 100%)
Pfam:
- 26S proteasome regulatory subunit 7, OB domain
- ATPase family associated with various cellular activities (AAA)
- AAA+ lid domain
Chain: B
Length: 440 amino acids
Theoretical weight: 49.26 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
Length: 440 amino acids
Theoretical weight: 49.26 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P62191 (Residues: 1-440; Coverage: 100%)
Pfam:
- ATPase family associated with various cellular activities (AAA)
- AAA+ lid domain
- Proteasomal ATPase OB C-terminal domain
Chain: D
Length: 418 amino acids
Theoretical weight: 47.43 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
Length: 418 amino acids
Theoretical weight: 47.43 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P43686 (Residues: 1-418; Coverage: 100%)
Pfam:
- ATPase family associated with various cellular activities (AAA)
- AAA+ lid domain
- Proteasomal ATPase OB C-terminal domain
Chain: E
Length: 403 amino acids
Theoretical weight: 45.87 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
Length: 403 amino acids
Theoretical weight: 45.87 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P62333 (Residues: 1-389; Coverage: 100%)
Pfam:
- ATPase family associated with various cellular activities (AAA)
- AAA+ lid domain
- Proteasomal ATPase OB C-terminal domain
Chain: F
Length: 439 amino acids
Theoretical weight: 49.27 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
Length: 439 amino acids
Theoretical weight: 49.27 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P17980 (Residues: 1-439; Coverage: 100%)
Pfam:
- ATPase family associated with various cellular activities (AAA)
- AAA+ lid domain
- Proteasomal ATPase OB C-terminal domain
Chain: C
Length: 398 amino acids
Theoretical weight: 44.85 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
Length: 398 amino acids
Theoretical weight: 44.85 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P62195 (Residues: 9-406; Coverage: 98%)
Pfam:
- ATPase family associated with various cellular activities (AAA)
- AAA+ lid domain
- Proteasomal ATPase OB C-terminal domain
Chain: U
Length: 953 amino acids
Theoretical weight: 105.96 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
Length: 953 amino acids
Theoretical weight: 105.96 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q99460 (Residues: 1-953; Coverage: 100%)
Pfam:
- 26S proteasome subunit RPN2, N-terminal domain
- Proteasome/cyclosome repeat
- HEAT repeats
- 26S proteasome regulatory subunit RPN2 C-terminal domain
Chain: V
Length: 533 amino acids
Theoretical weight: 60.94 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 533 amino acids
Theoretical weight: 60.94 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
O43242 (Residues: 2-534; Coverage: 100%)
Pfam:
InterPro:
Chain: W
Length: 456 amino acids
Theoretical weight: 52.98 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 456 amino acids
Theoretical weight: 52.98 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
O00232 (Residues: 1-456; Coverage: 100%)
Pfam:
InterPro:
Chain: X
Length: 422 amino acids
Theoretical weight: 47.53 KDa
Source organism: Homo sapiens
UniProt: Gene name: PSMD11
Pfam:
Length: 422 amino acids
Theoretical weight: 47.53 KDa
Source organism: Homo sapiens
UniProt: Gene name: PSMD11
Pfam:
- PCI domain
- 26S proteasome regulatory subunit RPN6 N-terminal domain
- 26S proteasome subunit RPN6 C-terminal helix domain
Chain: Y
Length: 389 amino acids
Theoretical weight: 45.59 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
Length: 389 amino acids
Theoretical weight: 45.59 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q15008 (Residues: 1-389; Coverage: 100%)
Pfam:
- PCI domain
- 26S proteasome subunit RPN7
- 26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix
Chain: Z
Length: 324 amino acids
Theoretical weight: 37.09 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 324 amino acids
Theoretical weight: 37.09 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P51665 (Residues: 1-324; Coverage: 100%)
Pfam:
InterPro:
Chain: a
Length: 376 amino acids
Theoretical weight: 43 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 376 amino acids
Theoretical weight: 43 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q9UNM6 (Residues: 1-376; Coverage: 100%)
Pfam:
InterPro:
Chain: b
Length: 377 amino acids
Theoretical weight: 40.78 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 377 amino acids
Theoretical weight: 40.78 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P55036 (Residues: 1-377; Coverage: 100%)
Pfam:
InterPro:
Chain: c
Length: 309 amino acids
Theoretical weight: 34.49 KDa
Source organism: Homo sapiens
UniProt:
Pfam: JAB1/Mov34/MPN/PAD-1 ubiquitin protease
InterPro:
Length: 309 amino acids
Theoretical weight: 34.49 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
O00487 (Residues: 2-310; Coverage: 100%)
Pfam: JAB1/Mov34/MPN/PAD-1 ubiquitin protease
InterPro:
Chain: d
Length: 349 amino acids
Theoretical weight: 39.54 KDa
Source organism: Homo sapiens
UniProt:
Pfam: CSN8/PSMD8/EIF3K family
InterPro:
Length: 349 amino acids
Theoretical weight: 39.54 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P48556 (Residues: 2-350; Coverage: 100%)
Pfam: CSN8/PSMD8/EIF3K family
InterPro:
Chain: e
Length: 70 amino acids
Theoretical weight: 8.28 KDa
Source organism: Homo sapiens
UniProt:
Pfam: DSS1/SEM1 family
InterPro: DSS1/SEM1
Length: 70 amino acids
Theoretical weight: 8.28 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P60896 (Residues: 1-70; Coverage: 100%)
Pfam: DSS1/SEM1 family
InterPro: DSS1/SEM1
Chain: f
Length: 749 amino acids
Theoretical weight: 82.28 KDa
Source organism: Homo sapiens
UniProt: Gene names: PSMD2, TRAP2
Pfam:
Length: 749 amino acids
Theoretical weight: 82.28 KDa
Source organism: Homo sapiens
UniProt: Gene names: PSMD2, TRAP2
Pfam:
- Proteasome/cyclosome repeat
- RPN1 N-terminal domain
- 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal