EC 1.17.1.8: 4-hydroxy-tetrahydrodipicolinate reductase
Reaction catalysed:
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)(+) + H(2)O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H
Systematic name:
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NADP(+) 4-oxidoreductase
Alternative Name(s):
- 2,3,4,5-tetrahydrodipicolinate:NAD(P)(+) oxidoreductase
- DapB (gene name)
- Dihydrodipicolinate reductase
- Dihydrodipicolinic acid reductase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 5tem contains 2 copies of Pfam domain PF05173 (Dihydrodipicolinate reductase, C-terminus) in 4-hydroxy-tetrahydrodipicolinate reductase. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/5tem_1_A_Pfam_PF05173_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5tem</span> contains 2 copies of Pfam domain <span class='highlight'>PF05173 (Dihydrodipicolinate reductase, C-terminus)</span> in <span class='highlight'>4-hydroxy-tetrahydrodipicolinate reductase</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 5tem contains 2 copies of Pfam domain PF01113 (Dihydrodipicolinate reductase, N-terminus) in 4-hydroxy-tetrahydrodipicolinate reductase. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/5tem_1_A_Pfam_PF01113_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5tem</span> contains 2 copies of Pfam domain <span class='highlight'>PF01113 (Dihydrodipicolinate reductase, N-terminus)</span> in <span class='highlight'>4-hydroxy-tetrahydrodipicolinate reductase</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
InterPro annotations
Structure domains
CATH domains
3.40.50.720
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Rossmann fold
Homology:
NAD(P)-binding Rossmann-like Domain
Occurring in:
![The deposited structure of PDB entry 5tem contains 2 copies of CATH domain 3.40.50.720 (Rossmann fold) in 4-hydroxy-tetrahydrodipicolinate reductase. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/5tem_1_A_CATH_3.40.50.720_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5tem</span> contains 2 copies of CATH domain <span class='highlight'>3.40.50.720 (Rossmann fold)</span> in <span class='highlight'>4-hydroxy-tetrahydrodipicolinate reductase</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 5tem contains 2 copies of CATH domain 3.30.360.10 (Dihydrodipicolinate Reductase; domain 2) in 4-hydroxy-tetrahydrodipicolinate reductase. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/5tem_1_A_CATH_3.30.360.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5tem</span> contains 2 copies of CATH domain <span class='highlight'>3.30.360.10 (Dihydrodipicolinate Reductase; domain 2)</span> in <span class='highlight'>4-hydroxy-tetrahydrodipicolinate reductase</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")