› › Structure analysis

Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with 7-methyl-GTP

X-ray diffraction
1.87Å resolution
PDB entry 5tfb coloured by chain, front view.
PDB entry 5tfb coloured by chain, side view.
PDB entry 5tfb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Cystic fibrosis transmembrane conductance regulator
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 10351.34 Å2
Buried surface area: 761.59 Å2
Dissociation area: 73.16 Å2
Dissociation energy (ΔGdiss): 11.62 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-146638

Macromolecules

Cystic fibrosis transmembrane conductance regulator
Chain: A
Length: 229 amino acids
Theoretical weight: 25.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P13569 (Residues: 387-646; Coverage: 15%)
Gene names: ABCC7, CFTR
Pfam: ABC transporter
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Cystic fibrosis transmembrane conductance regulator in PDB entry 5tfb, assembly 1, front view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 5tfb, assembly 1, side view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 5tfb, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P13569  
122920406080100120140160180200220
 
100200
UniProt
P13569
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Molecule details ›

Search similar proteins

Quick links