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Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-4

X-ray diffraction
3.3Å resolution
PDB entry 5toj coloured by chain, front view.
PDB entry 5toj coloured by chain, side view.
PDB entry 5toj coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fusion glycoprotein F1 and IG-heavy chain
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Multimeric state: hetero hexamer
Accessible surface area: 71217.88 Å2
Buried surface area: 24311.3 Å2
Dissociation area: 3,496.61 Å2
Dissociation energy (ΔGdiss): -5.03 kcal/mol
Dissociation entropy (TΔSdiss): 37.72 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-230767

Macromolecules

Fusion glycoprotein F0
Chains: A, B, C
Length: 550 amino acids
Theoretical weight: 61.05 KDa
Source organism: human respiratory syncytial virus
Expression system: Homo sapiens
UniProt:
  • Canonical: P03420 (Residues: 1-516; Coverage: 89%)
Gene name: F
Pfam: Fusion glycoprotein F0
InterPro:
Fusion glycoprotein F0 in PDB entry 5toj, assembly 1, front view.
Fusion glycoprotein F0 in PDB entry 5toj, assembly 1, side view.
Fusion glycoprotein F0 in PDB entry 5toj, assembly 1, top view.
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Single-domain antibody F-VHH-4
Chains: D, E, F
Length: 131 amino acids
Theoretical weight: 14.44 KDa
Source organism: Lama glama
Expression system: Komagataella phaffii GS115
InterPro:
CATH: Immunoglobulins
Single-domain antibody F-VHH-4 in PDB entry 5toj, assembly 1, front view.
Single-domain antibody F-VHH-4 in PDB entry 5toj, assembly 1, side view.
Single-domain antibody F-VHH-4 in PDB entry 5toj, assembly 1, top view.
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