Function and Biology

Zinc and the Iron Donor Frataxin Regulate Oligomerization of the Scaffold Protein to Form New Fe-S Cluster Assembly Centers

Source organism: Saccharomyces cerevisiae
Biochemical function: iron-sulfur cluster binding
Biological process: iron-sulfur cluster assembly
Cellular component: mitochondrion

EC 1.16.3.1: Ferroxidase

Reaction catalysed:
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Systematic name:
Fe(II):oxygen oxidoreductase
Alternative Name(s):
  • Caeruloplasmin
  • Ceruloplasmin
  • Ferro:O(2) oxidoreductase
  • Ferroxidase I
  • HEPH
  • Hephaestin
  • Iron II:oxygen oxidoreductase
  • Iron oxidase
  • Iron(II):oxygen oxidoreductase

Sequence families

Pfam Protein families (Pfam)
PF01592
Domain description: NifU-like N terminal domain
Occurring in:
  1. Iron sulfur cluster assembly protein 1, mitochondrial
The deposited structure of PDB entry 5tre contains 24 copies of Pfam domain PF01592 (NifU-like N terminal domain) in Iron sulfur cluster assembly protein 1, mitochondrial. Showing 1 copy in chain A [auth a].

PF01491
Domain description: Frataxin-like domain
Occurring in:
  1. Frataxin homolog, mitochondrial
The deposited structure of PDB entry 5tre contains 24 copies of Pfam domain PF01491 (Frataxin-like domain) in Frataxin homolog, mitochondrial. Showing 1 copy in chain B [auth A].

InterPro InterPro annotations
IPR002908
Domain description: Frataxin/CyaY
Occurring in:
  1. Frataxin homolog, mitochondrial
IPR002871
Domain description: NIF system FeS cluster assembly, NifU, N-terminal
Occurring in:
  1. Iron sulfur cluster assembly protein 1, mitochondrial
IPR036524
Domain description: Frataxin/CyaY superfamily
Occurring in:
  1. Frataxin homolog, mitochondrial
IPR011339
Domain description: Iron-sulfur cluster assembly scaffold protein IscU
Occurring in:
  1. Iron sulfur cluster assembly protein 1, mitochondrial
IPR020895
Domain description: Frataxin conserved site
Occurring in:
  1. Frataxin homolog, mitochondrial
IPR017789
Domain description: Frataxin
Occurring in:
  1. Frataxin homolog, mitochondrial