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Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer

X-ray diffraction
2.408Å resolution
PDB entry 5tvm coloured by chain, front view.
PDB entry 5tvm coloured by chain, side view.
PDB entry 5tvm coloured by chain, top view.
Source organism: Trypanosoma brucei brucei TREU927
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: S-adenosylmethionine decarboxylase proenzyme-like, putative and S-adenosylmethionine decarboxylase beta chain
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Multimeric state: hetero trimer
Accessible surface area: 26339.42 Å2
Buried surface area: 11778.19 Å2
Dissociation area: 1,675.42 Å2
Dissociation energy (ΔGdiss): 17.93 kcal/mol
Dissociation entropy (TΔSdiss): 13.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-176689
Assembly 2
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Assembly Name: S-adenosylmethionine decarboxylase proenzyme-like, putative and S-adenosylmethionine decarboxylase beta chain
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Multimeric state: hetero trimer
Accessible surface area: 26515.65 Å2
Buried surface area: 11607.08 Å2
Dissociation area: 1,610.11 Å2
Dissociation energy (ΔGdiss): 18.56 kcal/mol
Dissociation entropy (TΔSdiss): 13.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-176689

Macromolecules

S-adenosylmethionine decarboxylase beta chain
Chains: A, C
Length: 85 amino acids
Theoretical weight: 9.75 KDa
Source organism: Trypanosoma brucei brucei TREU927
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q587A7 (Residues: 1-85; Coverage: 23%)
Gene names: Tb06.26G9.820, Tb06.26G9.910, Tb927.6.4410, Tb927.6.4460
InterPro:
S-adenosylmethionine decarboxylase beta chain in PDB entry 5tvm, assembly 1, front view.
S-adenosylmethionine decarboxylase beta chain in PDB entry 5tvm, assembly 1, side view.
S-adenosylmethionine decarboxylase beta chain in PDB entry 5tvm, assembly 1, top view.
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S-adenosylmethionine decarboxylase alpha chain
Chains: B, D
Length: 285 amino acids
Theoretical weight: 32.04 KDa
Source organism: Trypanosoma brucei brucei TREU927
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q587A7 (Residues: 87-370; Coverage: 77%)
Gene names: Tb06.26G9.820, Tb06.26G9.910, Tb927.6.4410, Tb927.6.4460
Pfam: Adenosylmethionine decarboxylase
InterPro:
CATH: S-adenosylmethionine decarboxylase
S-adenosylmethionine decarboxylase alpha chain in PDB entry 5tvm, assembly 1, front view.
S-adenosylmethionine decarboxylase alpha chain in PDB entry 5tvm, assembly 1, side view.
S-adenosylmethionine decarboxylase alpha chain in PDB entry 5tvm, assembly 1, top view.
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S-adenosylmethionine decarboxylase proenzyme-like, putative
Chains: E, F
Length: 325 amino acids
Theoretical weight: 36.34 KDa
Source organism: Trypanosoma brucei brucei TREU927
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q587B3 (Residues: 1-325; Coverage: 100%)
Gene names: Tb06.26G9.750, Tb927.6.4470
Pfam: Adenosylmethionine decarboxylase
InterPro:
S-adenosylmethionine decarboxylase proenzyme-like, putative in PDB entry 5tvm, assembly 1, front view.
S-adenosylmethionine decarboxylase proenzyme-like, putative in PDB entry 5tvm, assembly 1, side view.
S-adenosylmethionine decarboxylase proenzyme-like, putative in PDB entry 5tvm, assembly 1, top view.
Molecule details ›

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