5u4w › Citations

Structure of the immature Zika virus at 9 Å resolution.

Prasad VM, Miller AS, Klose T, Sirohi D, Buda G, Jiang W, Kuhn RJ, Rossmann MG
Nat Struct Mol Biol 24 184-186 (2017)
Cited: 92 times
EuropePMC logo PMID: 28067914

Abstract

The current Zika virus (ZIKV) epidemic is characterized by severe pathogenicity in both children and adults. Sequence changes in ZIKV since its first isolation are apparent when pre-epidemic strains are compared with those causing the current epidemic. However, the residues that are responsible for ZIKV pathogenicity are largely unknown. Here we report the cryo-electron microscopy (cryo-EM) structure of the immature ZIKV at 9-Å resolution. The cryo-EM map was fitted with the crystal structures of the precursor membrane and envelope glycoproteins and was shown to be similar to the structures of other known immature flaviviruses. However, the immature ZIKV contains a partially ordered capsid protein shell that is less prominent in other immature flaviviruses. Furthermore, six amino acids near the interface between pr domains at the top of the spikes were found to be different between the pre-epidemic and epidemic ZIKV, possibly influencing the composition and structure of the resulting viruses.

Reviews - 5u4w mentioned but not cited (6)

  1. Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines. Rey FA, Lok SM. Cell 172 1319-1334 (2018)
  2. Humoral cross-reactivity between Zika and dengue viruses: implications for protection and pathology. Priyamvada L, Hudson W, Ahmed R, Wrammert J. Emerg Microbes Infect 6 e33 (2017)
  3. Monoclonal Antibodies against Zika Virus: Therapeutics and Their Implications for Vaccine Design. Wang Q, Yan J, Gao GF. J Virol 91 e01049-17 (2017)
  4. Zika Virus Structure, Maturation, and Receptors. Sirohi D, Kuhn RJ. J. Infect. Dis. 216 S935-S944 (2017)
  5. Structure-guided paradigm shifts in flavivirus assembly and maturation mechanisms. Nicholls CMR, Sevvana M, Kuhn RJ. Adv Virus Res 108 33-83 (2020)
  6. A Roadmap for Tick-Borne Flavivirus Research in the "Omics" Era. Grabowski JM, Hill CA. Front Cell Infect Microbiol 7 519 (2017)

Articles - 5u4w mentioned but not cited (10)

  1. Structure of the immature Zika virus at 9 Å resolution. Prasad VM, Miller AS, Klose T, Sirohi D, Buda G, Jiang W, Kuhn RJ, Rossmann MG. Nat Struct Mol Biol 24 184-186 (2017)
  2. Differential human antibody repertoires following Zika infection and the implications for serodiagnostics and disease outcome. Ravichandran S, Hahn M, Belaunzarán-Zamudio PF, Ramos-Castañeda J, Nájera-Cancino G, Caballero-Sosa S, Navarro-Fuentes KR, Ruiz-Palacios G, Golding H, Beigel JH, Khurana S. Nat Commun 10 1943 (2019)
  3. Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope. Tharakaraman K, Watanabe S, Chan KR, Huan J, Subramanian V, Chionh YH, Raguram A, Quinlan D, McBee M, Ong EZ, Gan ES, Tan HC, Tyagi A, Bhushan S, Lescar J, Vasudevan SG, Ooi EE, Sasisekharan R. Cell Host Microbe 23 618-627.e6 (2018)
  4. Neuroinvasiveness of the MR766 strain of Zika virus in IFNAR-/- mice maps to prM residues conserved amongst African genotype viruses. Nakayama E, Kato F, Tajima S, Ogawa S, Yan K, Takahashi K, Sato Y, Suzuki T, Kawai Y, Inagaki T, Taniguchi S, Le TT, Tang B, Prow NA, Uda A, Maeki T, Lim CK, Khromykh AA, Suhrbier A, Saijo M. PLoS Pathog 17 e1009788 (2021)
  5. Drugs to limit Zika virus infection and implication for maternal-fetal health. Kumar A, Kumar D, Jose J, Giri R, Mysorekar IU. Front Virol 2 928599 (2022)
  6. Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery. Vaney MC, Dellarole M, Duquerroy S, Medits I, Tsouchnikas G, Rouvinski A, England P, Stiasny K, Heinz FX, Rey FA. Nat Commun 13 3718 (2022)
  7. Identification and characterization of key residues in Zika virus envelope protein for virus assembly and entry. Ma X, Yuan Z, Yi Z. Emerg Microbes Infect 11 1604-1620 (2022)
  8. Identification of a critical role for ZIKV capsid α3 in virus assembly and its genetic interaction with M protein. Jablunovsky A, Narayanan A, Jose J. PLoS Negl Trop Dis 18 e0011873 (2024)
  9. Insights from the sequence similarity of Zika virus proteins with the Human nerve proteins. Marsakatla P, Suneetha S, Lee J, Swaminathan PD, Vasudevan L, Supriya R, Suneetha LM. Bioinformation 14 194-200 (2018)
  10. Somatic Hypermutation and Framework Mutations of Variable Region Contribute to Anti-Zika Virus-Specific Monoclonal Antibody Binding and Function. Tsuji I, Vang F, Dominguez D, Karwal L, Sanjali A, Livengood JA, Davidson E, Fouch ME, Doranz BJ, Das SC, Dean HJ. J Virol 96 e0007122 (2022)


Reviews citing this publication (26)

  1. The continued threat of emerging flaviviruses. Pierson TC, Diamond MS. Nat Microbiol 5 796-812 (2020)
  2. The emergence of Zika virus and its new clinical syndromes. Pierson TC, Diamond MS. Nature 560 573-581 (2018)
  3. Structural biology of Zika virus and other flaviviruses. Hasan SS, Sevvana M, Kuhn RJ, Rossmann MG. Nat. Struct. Mol. Biol. 25 13-20 (2018)
  4. Immune Response to Dengue and Zika. Ngono AE, Shresta S. Annu. Rev. Immunol. 36 279-308 (2018)
  5. Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic? Saiz JC, Martín-Acebes MA, Bueno-Marí R, Salomón OD, Villamil-Jiménez LC, Heukelbach J, Alencar CH, Armstrong PK, Ortiga-Carvalho TM, Mendez-Otero R, Rosado-de-Castro PH, Pimentel-Coelho PM. Front Microbiol 8 1554 (2017)
  6. Protective and enhancing interactions among dengue viruses 1-4 and Zika virus. Katzelnick LC, Bos S, Harris E. Curr Opin Virol 43 59-70 (2020)
  7. Structural Biology of the Zika Virus. Shi Y, Gao GF. Trends Biochem. Sci. 42 443-456 (2017)
  8. The evolution of Zika virus from Asia to the Americas. Liu ZY, Shi WF, Qin CF. Nat. Rev. Microbiol. 17 131-139 (2019)
  9. Atomic cryo-EM structures of viruses. Jiang W, Tang L. Curr. Opin. Struct. Biol. 46 122-129 (2017)
  10. Current Advances in Zika Vaccine Development. Wang Y, Ling L, Zhang Z, Marin-Lopez A. Vaccines (Basel) 10 1816 (2022)
  11. In situ analytical techniques for battery interface analysis. Tripathi AM, Su WN, Hwang BJ. Chem Soc Rev 47 736-851 (2018)
  12. Mapping the diverse structural landscape of the flavivirus antibody repertoire. Sevvana M, Kuhn RJ. Curr Opin Virol 45 51-64 (2020)
  13. Host-Directed Antivirals: A Realistic Alternative to Fight Zika Virus. Saiz JC, Oya NJ, Blázquez AB, Escribano-Romero E, Martín-Acebes MA. Viruses 10 (2018)
  14. Zika Virus: Immune Evasion Mechanisms, Currently Available Therapeutic Regimens, and Vaccines. Asif A, Manzoor S, Tuz-Zahra F, Saalim M, Ashraf M, Ishtiyaq J, Khalid M. Viral Immunol. 30 682-690 (2017)
  15. Current Efforts in the Development of Vaccines for the Prevention of Zika and Chikungunya Virus Infections. Schrauf S, Tschismarov R, Tauber E, Ramsauer K. Front Immunol 11 592 (2020)
  16. Defeat Dengue and Zika Viruses With a One-Two Punch of Vaccine and Vector Blockade. Sun J, Du S, Zheng Z, Cheng G, Jin X. Front Microbiol 11 362 (2020)
  17. Reverse Genetic Approaches for the Generation of Recombinant Zika Virus. Ávila-Pérez G, Nogales A, Martín V, Almazán F, Martínez-Sobrido L. Viruses 10 (2018)
  18. Capsid protein is central to the birth of flavivirus particles. Tan TY, Fibriansah G, Lok SM. PLoS Pathog 16 e1008542 (2020)
  19. Functional insights into pathogen biology from 3D electron microscopy. Cyrklaff M, Frischknecht F, Kudryashev M. FEMS Microbiol. Rev. 41 828-853 (2017)
  20. How Antibodies Recognize Pathogenic Viruses: Structural Correlates of Antibody Neutralization of HIV-1, SARS-CoV-2, and Zika. Abernathy ME, Dam KA, Esswein SR, Jette CA, Bjorkman PJ. Viruses 13 2106 (2021)
  21. In silico approaches to Zika virus drug discovery. Sinigaglia A, Riccetti S, Trevisan M, Barzon L. Expert Opin Drug Discov 13 825-835 (2018)
  22. The Many Faces of a Dynamic Virion: Implications of Viral Breathing on Flavivirus Biology and Immunogenicity. Dowd KA, Pierson TC. Annu Rev Virol 5 185-207 (2018)
  23. Chikungunya and Zika Viruses: Co-Circulation and the Interplay between Viral Proteins and Host Factors. Wichit S, Gumpangseth N, Hamel R, Yainoy S, Arikit S, Punsawad C, Missé D. Pathogens 10 448 (2021)
  24. The role of capsid in the flaviviral life cycle and perspectives for vaccine development. He Y, Wang M, Chen S, Cheng A. Vaccine 38 6872-6881 (2020)
  25. Tick-Borne Encephalitis Virus: A Structural View. Pulkkinen LIA, Butcher SJ, Anastasina M. Viruses 10 (2018)
  26. Zika Virus Transmission Through Blood Tissue Barriers. Khaiboullina SF, Ribeiro FM, Uppal T, Martynova EV, Rizvanov AA, Verma SC. Front Microbiol 10 1465 (2019)

Articles citing this publication (50)

  1. Modified mRNA Vaccines Protect against Zika Virus Infection. Richner JM, Himansu S, Dowd KA, Butler SL, Salazar V, Fox JM, Julander JG, Tang WW, Shresta S, Pierson TC, Ciaramella G, Diamond MS. Cell 168 1114-1125.e10 (2017)
  2. A single mutation in the prM protein of Zika virus contributes to fetal microcephaly. Yuan L, Huang XY, Liu ZY, Zhang F, Zhu XL, Yu JY, Ji X, Xu YP, Li G, Li C, Wang HJ, Deng YQ, Wu M, Cheng ML, Ye Q, Xie DY, Li XF, Wang X, Shi W, Hu B, Shi PY, Xu Z, Qin CF. Science 358 933-936 (2017)
  3. Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease. Richner JM, Jagger BW, Shan C, Fontes CR, Dowd KA, Cao B, Himansu S, Caine EA, Nunes BTD, Medeiros DBA, Muruato AE, Foreman BM, Luo H, Wang T, Barrett AD, Weaver SC, Vasconcelos PFC, Rossi SL, Ciaramella G, Mysorekar IU, Pierson TC, Shi PY, Diamond MS. Cell 170 273-283.e12 (2017)
  4. Functional Profiling of Antibody Immune Repertoires in Convalescent Zika Virus Disease Patients. Fahad AS, Timm MR, Madan B, Burgomaster KE, Dowd KA, Normandin E, Gutiérrez-González MF, Pennington JM, De Souza MO, Henry AR, Laboune F, Wang L, Ambrozak DR, Gordon IJ, Douek DC, Ledgerwood JE, Graham BS, Castilho LR, Pierson TC, Mascola JR, DeKosky BJ. Front Immunol 12 615102 (2021)
  5. A New In Vivo Model to Study Protective Immunity to Zika Virus Infection in Mice With Intact Type I Interferon Signaling. Nazerai L, Schøller AS, Rasmussen POS, Buus S, Stryhn A, Christensen JP, Thomsen AR. Front Immunol 9 593 (2018)
  6. Identification of a pocket factor that is critical to Zika virus assembly. DiNunno NM, Goetschius DJ, Narayanan A, Majowicz SA, Moustafa I, Bator CM, Hafenstein SL, Jose J. Nat Commun 11 4953 (2020)
  7. Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins. Renner M, Dejnirattisai W, Carrique L, Martin IS, Karia D, Ilca SL, Ho SF, Kotecha A, Keown JR, Mongkolsapaya J, Screaton GR, Grimes JM. Nat Commun 12 1238 (2021)
  8. A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission. Xie X, Kum DB, Xia H, Luo H, Shan C, Zou J, Muruato AE, Medeiros DBA, Nunes BTD, Dallmeier K, Rossi SL, Weaver SC, Neyts J, Wang T, Vasconcelos PFC, Shi PY. Cell Host Microbe 24 487-499.e5 (2018)
  9. Refinement and Analysis of the Mature Zika Virus Cryo-EM Structure at 3.1 Å Resolution. Sevvana M, Long F, Miller AS, Klose T, Buda G, Sun L, Kuhn RJ, Rossmann MG. Structure 26 1169-1177.e3 (2018)
  10. The structure of an infectious immature flavivirus redefines viral architecture and maturation. Newton ND, Hardy JM, Modhiran N, Hugo LE, Amarilla AA, Bibby S, Venugopal H, Harrison JJ, Traves RJ, Hall RA, Hobson-Peters J, Coulibaly F, Watterson D. Sci Adv 7 eabe4507 (2021)
  11. Zika Virus Hijacks Extracellular Vesicle Tetraspanin Pathways for Cell-to-Cell Transmission. York SB, Sun L, Cone AS, Duke LC, Cheerathodi MR, Meckes DG. mSphere e0019221 (2021)
  12. Zika virus induced cellular remodelling. Rossignol ED, Peters KN, Connor JH, Bullitt E. Cell. Microbiol. 19 (2017)
  13. Capsid protein structure in Zika virus reveals the flavivirus assembly process. Tan TY, Fibriansah G, Kostyuchenko VA, Ng TS, Lim XX, Zhang S, Lim XN, Wang J, Shi J, Morais MC, Corti D, Lok SM. Nat Commun 11 895 (2020)
  14. Functional Genomics and Immunologic Tools: The Impact of Viral and Host Genetic Variations on the Outcome of Zika Virus Infection. Yun SI, Song BH, Frank JC, Julander JG, Olsen AL, Polejaeva IA, Davies CJ, White KL, Lee YM. Viruses 10 (2018)
  15. Single Amino Acid Mutations Affect Zika Virus Replication In Vitro and Virulence In Vivo. Collette NM, Lao VHI, Weilhammer DR, Zingg B, Cohen SD, Hwang M, Coffey LL, Grady SL, Zemla AT, Borucki MK. Viruses 12 E1295 (2020)
  16. Structural basis of a potent human monoclonal antibody against Zika virus targeting a quaternary epitope. Long F, Doyle M, Fernandez E, Miller AS, Klose T, Sevvana M, Bryan A, Davidson E, Doranz BJ, Kuhn RJ, Diamond MS, Crowe JE, Rossmann MG. Proc. Natl. Acad. Sci. U.S.A. 116 1591-1596 (2019)
  17. Zika Virus Baculovirus-Expressed Virus-Like Particles Induce Neutralizing Antibodies in Mice. Dai S, Zhang T, Zhang Y, Wang H, Deng F. Virol Sin 33 213-226 (2018)
  18. Functional Correlation between Subcellular Localizations of Japanese Encephalitis Virus Capsid Protein and Virus Production. Ishida K, Goto S, Ishimura M, Amanuma M, Hara Y, Suzuki R, Katoh K, Morita E. J Virol 93 (2019)
  19. Architecture of severe fever with thrombocytopenia syndrome virus. Sun Z, Cheng J, Bai Y, Cao L, Xie D, Deng F, Zhang X, Rao Z, Lou Z. Protein Cell 14 914-918 (2023)
  20. Dengue immune sera enhance Zika virus infection in human peripheral blood monocytes through Fc gamma receptors. Li M, Zhao L, Zhang C, Wang X, Hong W, Sun J, Liu R, Yu L, Wang J, Zhang F, Jin X. PLoS ONE 13 e0200478 (2018)
  21. Development of a potent Zika virus vaccine using self-amplifying messenger RNA. Luisi K, Morabito KM, Burgomaster KE, Sharma M, Kong WP, Foreman BM, Patel S, Fisher B, Aleshnick MA, Laliberte J, Wallace M, Ruckwardt TJ, Gordon DN, Linton C, Ruggiero N, Cohen JL, Johnson R, Aggarwal K, Ko SY, Yang ES, Pelc RS, Dowd KA, O'Hagan D, Ulmer J, Mossman S, Sambor A, Lepine E, Mascola JR, Pierson TC, Graham BS, Yu D. Sci Adv 6 eaba5068 (2020)
  22. Dengue and Zika virus capsid proteins bind to membranes and self-assemble into liquid droplets with nucleic acids. Ambroggio EE, Costa Navarro GS, Pérez Socas LB, Bagatolli LA, Gamarnik AV. J Biol Chem 297 101059 (2021)
  23. Designing B- and T-cell multi-epitope based subunit vaccine using immunoinformatics approach to control Zika virus infection. Kumar Pandey R, Ojha R, Mishra A, Kumar Prajapati V. J. Cell. Biochem. 119 7631-7642 (2018)
  24. Development, Characterization, and Application of Two Reporter-Expressing Recombinant Zika Viruses. Yun SI, Song BH, Woolley ME, Frank JC, Julander JG, Lee YM. Viruses 12 (2020)
  25. Flaviviruses have imperfect icosahedral symmetry. Therkelsen MD, Klose T, Vago F, Jiang W, Rossmann MG, Kuhn RJ. Proc. Natl. Acad. Sci. U.S.A. 115 11608-11612 (2018)
  26. Structural Basis of Zika Virus Specific Neutralization in Subsequent Flavivirus Infections. Sevvana M, Rogers TF, Miller AS, Long F, Klose T, Beutler N, Lai YC, Parren M, Walker LM, Buda G, Burton DR, Rossmann MG, Kuhn RJ. Viruses 12 E1346 (2020)
  27. Zika virus infects pericytes in the choroid plexus and enters the central nervous system through the blood-cerebrospinal fluid barrier. Kim J, Alejandro B, Hetman M, Hattab EM, Joiner J, Schroten H, Ishikawa H, Chung DH. PLoS Pathog. 16 e1008204 (2020)
  28. A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy. Hassan AO, Dmitriev IP, Kashentseva EA, Zhao H, Brough DE, Fremont DH, Curiel DT, Diamond MS. Cell Rep 28 2634-2646.e4 (2019)
  29. Adaptation to host cell environment during experimental evolution of Zika virus. Grass V, Hardy E, Kobert K, Talemi SR, Décembre E, Guy C, Markov PV, Kohl A, Paris M, Böckmann A, Muñoz-González S, Sherry L, Höfer T, Boussau B, Dreux M. Commun Biol 5 1115 (2022)
  30. Antigenicity, stability, and reproducibility of Zika reporter virus particles for long-term applications. Whitbeck JC, Thomas A, Kadash-Edmondson K, Grinyo-Escuer A, Stafford LJ, Cheng C, Liao GC, Holtsberg FW, Aman MJ, Simmons G, Davidson E, Doranz BJ. PLoS Negl Trop Dis 14 e0008730 (2020)
  31. Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics. Durham ND, Agrawal A, Waltari E, Croote D, Zanini F, Fouch M, Davidson E, Smith O, Carabajal E, Pak JE, Doranz BJ, Robinson M, Sanz AM, Albornoz LL, Rosso F, Einav S, Quake SR, McCutcheon KM, Goo L. Elife 8 (2019)
  32. Construction of a recombinant avipoxvirus expressing the env gene of Zika virus as a novel putative preventive vaccine. Zanotto C, Paolini F, Radaelli A, De Giuli Morghen C. Virol J 18 50 (2021)
  33. Crystal Structure of the Japanese Encephalitis Virus Capsid Protein. Poonsiri T, Wright GSA, Solomon T, Antonyuk SV. Viruses 11 (2019)
  34. Dengue, Yellow Fever, Zika and Chikungunya epidemic arboviruses in Brazil: ultrastructural aspects. Barreto-Vieira DF, Couto-Lima D, Jácome FC, Caldas GC, Barth OM. Mem Inst Oswaldo Cruz 115 e200278 (2021)
  35. Determinants of Zika virus host tropism uncovered by deep mutational scanning. Setoh YX, Amarilla AA, Peng NYG, Griffiths RE, Carrera J, Freney ME, Nakayama E, Ogawa S, Watterson D, Modhiran N, Nanyonga FE, Torres FJ, Slonchak A, Periasamy P, Prow NA, Tang B, Harrison J, Hobson-Peters J, Cuddihy T, Cooper-White J, Hall RA, Young PR, Mackenzie JM, Wolvetang E, Bloom JD, Suhrbier A, Khromykh AA. Nat Microbiol 4 876-887 (2019)
  36. Glycerol Monolaurate, an Analogue to a Factor Secreted by Lactobacillus, Is Virucidal against Enveloped Viruses, Including HIV-1. Welch JL, Xiang J, Okeoma CM, Schlievert PM, Stapleton JT. mBio 11 (2020)
  37. Intrinsic features of Zika Virus non-structural proteins NS2A and NS4A in the regulation of viral replication. Yu Y, Gao C, Wen C, Zou P, Qi X, Cardona CJ, Xing Z. PLoS Negl Trop Dis 16 e0010366 (2022)
  38. Leu-to-Phe substitution at prM146 decreases the growth ability of Zika virus and partially reduces its pathogenicity in mice. Inagaki T, Taniguchi S, Kawai Y, Maeki T, Nakayama E, Tajima S, Takeyama H, Lim CK, Saijo M. Sci Rep 11 19635 (2021)
  39. Performance of an Automated Zika IgG Immunoassay in the Detection of Zika IgG Specific Antibodies-A Validation Approach in Samples from Prevalence Areas and Non-Endemic Countries. Laengin T, Augenstein S, Stadlbauer E, Girgnhuber H, Gloeck M, Riedel A. Trop Med Infect Dis 5 (2020)
  40. Probing Zika Virus Neutralization Determinants with Glycoprotein Mutants Bearing Linear Epitope Insertions. Chambers MT, Schwarz MC, Sourisseau M, Gray ES, Evans MJ. J. Virol. 92 (2018)
  41. Self-assembly of dengue virus empty capsid-like particles in solution. Neves-Martins TC, Mebus-Antunes NC, Neto CHG, Barbosa GM, Almeida FCL, Caruso IP, Da Poian AT. iScience 26 106197 (2023)
  42. Structures of enveloped virions determined by cryogenic electron microscopy and tomography. Stass R, Ng WM, Kim YC, Huiskonen JT. Adv Virus Res 105 35-71 (2019)
  43. The interaction of dengue virus capsid protein with negatively charged interfaces drives the in vitro assembly of nucleocapsid-like particles. Mebus-Antunes NC, Ferreira WS, Barbosa GM, Neves-Martins TC, Weissmuller G, Almeida FCL, Da Poian AT. PLoS One 17 e0264643 (2022)
  44. The low spike density of HIV may have evolved because of the effects of T helper cell depletion on affinity maturation. Amitai A, Chakraborty AK, Kardar M. PLoS Comput. Biol. 14 e1006408 (2018)
  45. Zika and Flavivirus Shell Disorder: Virulence and Fetal Morbidity. Goh GK, Dunker AK, Foster JA, Uversky VN. Biomolecules 9 (2019)
  46. Zika virus pathogenesis and current therapeutic advances. Mwaliko C, Nyaruaba R, Zhao L, Atoni E, Karungu S, Mwau M, Lavillette D, Xia H, Yuan Z. Pathog Glob Health 115 21-39 (2021)
  47. Zika virus prM protein contains cholesterol binding motifs required for virus entry and assembly. Goellner S, Enkavi G, Prasad V, Denolly S, Eu S, Mizzon G, Witte L, Kulig W, Uckeley ZM, Lavacca TM, Haselmann U, Lozach PY, Brügger B, Vattulainen I, Bartenschlager R. Nat Commun 14 7344 (2023)
  48. Zika virus-like particle vaccine fusion loop mutation increases production yield but fails to protect AG129 mice against Zika virus challenge. Thompson D, Guenther B, Manayani D, Mendy J, Smith J, Espinosa DA, Harris E, Alexander J, Vang L, Morello CS. PLoS Negl Trop Dis 16 e0010588 (2022)
  49. Zika virus-like particle vaccine protects AG129 mice and rhesus macaques against Zika virus. Vang L, Morello CS, Mendy J, Thompson D, Manayani D, Guenther B, Julander J, Sanford D, Jain A, Patel A, Shabram P, Smith J, Alexander J. PLoS Negl Trop Dis 15 e0009195 (2021)
  50. prM-reactive antibodies reveal a role for partially mature virions in dengue virus pathogenesis. A Dowd K, Sirohi D, D Speer S, VanBlargan LA, Chen RE, Mukherjee S, Whitener BM, Govero J, Aleshnick M, Larman B, Sukupolvi-Petty S, Sevvana M, Miller AS, Klose T, Zheng A, Koenig S, Kielian M, Kuhn RJ, Diamond MS, Pierson TC. Proc Natl Acad Sci U S A 120 e2218899120 (2023)


Quick links