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Cryo-EM Structure of Immature Zika Virus

Electron Microscopy
9.1Å resolution
PDB entry 5u4w coloured by chain, front view.
PDB entry 5u4w coloured by chain, side view.
PDB entry 5u4w coloured by chain, top view.
Source organism: Zika virus
Assembly composition:
hetero 720-mer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 720-mer
PDBe Complex ID: PDB-CPX-100070

Macromolecules

E protein
Chains: A, C, E
Length: 402 amino acids
Theoretical weight: 44.8 KDa
Source organism: Zika virus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: O11875 (Residues: 281-674; Coverage: 12%)
Pfam:
InterPro:
E protein in PDB entry 5u4w, assembly 1, front view.
E protein in PDB entry 5u4w, assembly 1, side view.
E protein in PDB entry 5u4w, assembly 1, top view.
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pr domain
Chains: B, D, F
Length: 81 amino acids
Theoretical weight: 9.26 KDa
Source organism: Zika virus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: A0A0B4L3F2 (Residues: 115-195; Coverage: 2%)
Pfam: Flavivirus polyprotein propeptide
InterPro:
pr domain in PDB entry 5u4w, assembly 1, front view.
pr domain in PDB entry 5u4w, assembly 1, side view.
pr domain in PDB entry 5u4w, assembly 1, top view.
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Envelope protein E
Chains: G, I, K
Length: 66 amino acids
Theoretical weight: 6.89 KDa
Source organism: Zika virus
UniProt:
  • Canonical: A0A024B7W1 (Residues: 726-791; Coverage: 2%)
Pfam: Flavivirus envelope glycoprotein E, stem/anchor domain
InterPro:
Envelope protein E in PDB entry 5u4w, assembly 1, front view.
Envelope protein E in PDB entry 5u4w, assembly 1, side view.
Envelope protein E in PDB entry 5u4w, assembly 1, top view.
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Small envelope protein M
Chains: H, J, L
Length: 53 amino acids
Theoretical weight: 5.98 KDa
Source organism: Zika virus
UniProt:
  • Canonical: A0A024B7W1 (Residues: 238-290; Coverage: 2%)
Pfam: Flavivirus envelope glycoprotein M
InterPro:
Small envelope protein M in PDB entry 5u4w, assembly 1, front view.
Small envelope protein M in PDB entry 5u4w, assembly 1, side view.
Small envelope protein M in PDB entry 5u4w, assembly 1, top view.
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