Function and Biology Details
Reaction catalysed:
Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Complement C1s subcomponent heavy chain (preferred)
PDBe Complex ID:
PDB-CPX-140781 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Complement C1s subcomponent light chain
Molecule details ›
Chain: A
Length: 252 amino acids
Theoretical weight: 27.84 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 252 amino acids
Theoretical weight: 27.84 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P09871 (Residues: 437-688; Coverage: 37%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Complement C1s subcomponent heavy chain
Molecule details ›
Chain: B
Length: 152 amino acids
Theoretical weight: 16.88 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1
Length: 152 amino acids
Theoretical weight: 16.88 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P09871 (Residues: 285-436; Coverage: 23%)
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1
