Assemblies
Assembly Name:
Tyrosine-protein kinase JAK2
Multimeric state:
monomeric
Accessible surface area:
14296.78 Å2
Buried surface area:
648.53 Å2
Dissociation area:
68.09
Å2
Dissociation energy (ΔGdiss):
-0.3
kcal/mol
Dissociation entropy (TΔSdiss):
0.89
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-130063
Assembly Name:
Tyrosine-protein kinase JAK2
Multimeric state:
monomeric
Accessible surface area:
14557.68 Å2
Buried surface area:
674.11 Å2
Dissociation area:
96.06
Å2
Dissociation energy (ΔGdiss):
1.07
kcal/mol
Dissociation entropy (TΔSdiss):
0.92
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-130063
Macromolecules
Chains: A, B
Length: 316 amino acids
Theoretical weight: 37.4 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
Length: 316 amino acids
Theoretical weight: 37.4 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
O60674 (Residues: 840-1132; Coverage: 26%)
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
- Protein kinase-like domain superfamily
- Janus kinase 2, catalytic domain
- Protein kinase domain
- Serine-threonine/tyrosine-protein kinase, catalytic domain
- Tyrosine-protein kinase, catalytic domain
- Protein kinase, ATP binding site
- Tyrosine-protein kinase, active site
