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Prolyl isomerase Pin1 R14A mutant bound with Brd4 peptide

X-ray diffraction
1.85Å resolution
PDB entry 5uy9 coloured by chain, front view.
PDB entry 5uy9 coloured by chain, side view.
PDB entry 5uy9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 and peptide
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Multimeric state: hetero dimer
Accessible surface area: 8378.63 Å2
Buried surface area: 2165.55 Å2
Dissociation area: 495.83 Å2
Dissociation energy (ΔGdiss): 4.19 kcal/mol
Dissociation entropy (TΔSdiss): 6.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-166186

Macromolecules

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Chain: A
Length: 163 amino acids
Theoretical weight: 18.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13526 (Residues: 1-163; Coverage: 100%)
Gene name: PIN1
Pfam:
InterPro:
CATH:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 in PDB entry 5uy9, assembly 1, front view.
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 in PDB entry 5uy9, assembly 1, side view.
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 in PDB entry 5uy9, assembly 1, top view.
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Brd4 peptide
Chain: B
Length: 7 amino acids
Theoretical weight: 860 Da
Source organism: Homo sapiens
Expression system: Not provided
Brd4 peptide in PDB entry 5uy9, assembly 1, front view.
Brd4 peptide in PDB entry 5uy9, assembly 1, side view.
Brd4 peptide in PDB entry 5uy9, assembly 1, top view.
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