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Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex

Electron Microscopy
4.1Å resolution
PDB entry 5uz7 coloured by chain, front view.
PDB entry 5uz7 coloured by chain, side view.
PDB entry 5uz7 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 45319.23 Å2
Buried surface area: 12745.76 Å2
Dissociation area: 1,361.85 Å2
Dissociation energy (ΔGdiss): -2.61 kcal/mol
Dissociation entropy (TΔSdiss): 12.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-211025

Macromolecules

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Chain: A
Length: 380 amino acids
Theoretical weight: 44.33 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P63092 (Residues: 1-394; Coverage: 96%)
Gene names: GNAS, GNAS1, GSP
Pfam: G-protein alpha subunit
InterPro:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 5uz7, assembly 1, front view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 5uz7, assembly 1, side view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 5uz7, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 351 amino acids
Theoretical weight: 38.74 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 5uz7, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 5uz7, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 5uz7, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 68 amino acids
Theoretical weight: 7.56 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P59768 (Residues: 1-68; Coverage: 96%)
Gene name: GNG2
Pfam: GGL domain
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 5uz7, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 5uz7, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 5uz7, assembly 1, top view.
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NANOBODY 35
Chain: N
Length: 138 amino acids
Theoretical weight: 15.14 KDa
Source organism: Lama glama
Expression system: Escherichia coli
InterPro:
NANOBODY 35 in PDB entry 5uz7, assembly 1, front view.
NANOBODY 35 in PDB entry 5uz7, assembly 1, side view.
NANOBODY 35 in PDB entry 5uz7, assembly 1, top view.
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Calcitonin receptor
Chain: R
Length: 501 amino acids
Theoretical weight: 58.47 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P30988 (Residues: 25-474; Coverage: 100%)
Gene name: CALCR
Pfam:
InterPro:
Calcitonin receptor in PDB entry 5uz7, assembly 1, front view.
Calcitonin receptor in PDB entry 5uz7, assembly 1, side view.
Calcitonin receptor in PDB entry 5uz7, assembly 1, top view.
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