Structure analysis

DNA polymerase beta binary complex with 8-oxoG at the primer terminus

X-ray diffraction
1.798Å resolution
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
3 distinct DNA molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 20805.53 Å2
Buried surface area: 4187.3 Å2
Dissociation area: 977.86 Å2
Dissociation energy (ΔGdiss): 10.48 kcal/mol
Dissociation entropy (TΔSdiss): 11.67 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-119258

Macromolecules

PDBe-KB: UniProt Coverage View: P06746  
133550100150200250300
 
100200300MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
UniProt
P06746
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Sequence conservation

Search similar proteins

Name: DNA (5'-D(*CP*CP*GP*AP*CP*GP*CP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3')
Representative chains: T
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 16 nucleotides
Theoretical weight: 4.83 KDa
116246810121416
 
51015CCGACGCCGCATCAGC
Chains
Chain B (auth T)
Interaction interfaces

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Name: DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(8OG))-3')
Representative chains: P
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 10 nucleotides
Theoretical weight: 3.12 KDa
11012345678910
 
510GCTGATGCG*
Chains
Chain C (auth P)
Interaction interfaces

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Name: DNA (5'-D(P*GP*TP*CP*GP*G)-3')
Representative chains: D
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 5 nucleotides
Theoretical weight: 1.54 KDa
151.01.52.02.53.03.54.04.55.0
 
246GTCGG
Chains
Chain D (auth D)
Ligand binding sites
Interaction interfaces

Search similar DNA