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Structural basis for a six letter alphabet including GATCKX

X-ray diffraction
1.749Å resolution
PDB entry 5vbs coloured by chain, front view.
PDB entry 5vbs coloured by chain, side view.
PDB entry 5vbs coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Reverse transcriptase/ribonuclease H and DNA
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Multimeric state: hetero trimer
Accessible surface area: 15083.55 Å2
Buried surface area: 1597.42 Å2
Dissociation area: 441.93 Å2
Dissociation energy (ΔGdiss): -8.87 kcal/mol
Dissociation entropy (TΔSdiss): 10.09 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-119273

Macromolecules

Reverse transcriptase/ribonuclease H
Chain: A
Length: 259 amino acids
Theoretical weight: 29.35 KDa
Source organism: Moloney murine leukemia virus isolate Shinnick
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P03355 (Residues: 683-937; Coverage: 15%)
Gene name: gag-pol
Pfam: Reverse transcriptase (RNA-dependent DNA polymerase)
InterPro:
CATH:
Reverse transcriptase/ribonuclease H in PDB entry 5vbs, assembly 1, front view.
Reverse transcriptase/ribonuclease H in PDB entry 5vbs, assembly 1, side view.
Reverse transcriptase/ribonuclease H in PDB entry 5vbs, assembly 1, top view.
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DNA chain B
Name: DNA (5'-D(*CP*TP*TP*AP*TP*(DX)P*(DX)P*T)-3')
Representative chains: B
Source organism: Escherichia coli [562]
Expression system: Not provided
Length: 8 nucleotides
Theoretical weight: 2.43 KDa
DNA (5'-D(*CP*TP*TP*AP*TP*(DX)P*(DX)P*T)-3') in PDB entry 5vbs, assembly 1, front view.
DNA (5'-D(*CP*TP*TP*AP*TP*(DX)P*(DX)P*T)-3') in PDB entry 5vbs, assembly 1, side view.
DNA (5'-D(*CP*TP*TP*AP*TP*(DX)P*(DX)P*T)-3') in PDB entry 5vbs, assembly 1, top view.
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DNA chain G
Name: DNA (5'-D(P*AP*(93D)P*(93D)P*AP*TP*AP*AP*G)-3')
Representative chains: G
Source organism: Escherichia coli [562]
Expression system: Not provided
Length: 8 nucleotides
Theoretical weight: 2.42 KDa
DNA (5'-D(P*AP*(93D)P*(93D)P*AP*TP*AP*AP*G)-3') in PDB entry 5vbs, assembly 1, front view.
DNA (5'-D(P*AP*(93D)P*(93D)P*AP*TP*AP*AP*G)-3') in PDB entry 5vbs, assembly 1, side view.
DNA (5'-D(P*AP*(93D)P*(93D)P*AP*TP*AP*AP*G)-3') in PDB entry 5vbs, assembly 1, top view.
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