› › Structure analysis

Human cyclic GMP-AMP synthase (cGAS) in complex with 2',5'-GpAp

X-ray diffraction
3.246Å resolution
PDB entry 5vdq coloured by chain, front view.
PDB entry 5vdq coloured by chain, side view.
PDB entry 5vdq coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Cyclic GMP-AMP synthase
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 17413.96 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-185433
Assembly 2
Download    3D Visualisation
Assembly Name: Cyclic GMP-AMP synthase
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 18109.2 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-185433

Macromolecules

Cyclic GMP-AMP synthase
Chains: A, B
Length: 363 amino acids
Theoretical weight: 42.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N884 (Residues: 161-522; Coverage: 69%)
Gene names: C6orf150, CGAS, MB21D1
Pfam:
InterPro:
CATH:
Cyclic GMP-AMP synthase in PDB entry 5vdq, assembly 1, front view.
Cyclic GMP-AMP synthase in PDB entry 5vdq, assembly 1, side view.
Cyclic GMP-AMP synthase in PDB entry 5vdq, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links