› › Structure analysis

Crystal structure of Protein Kinase A in complex with the PKI peptide and Aminobenzothiazole based inhibitors

X-ray diffraction
1.95Å resolution
PDB entry 5vi9 coloured by chain, front view.
PDB entry 5vi9 coloured by chain, side view.
PDB entry 5vi9 coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: cAMP-dependent protein kinase catalytic subunit alpha and cAMP-dependent protein kinase inhibitor alpha
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 15928.52 Å2
Buried surface area: 1569.75 Å2
Dissociation area: 784.87 Å2
Dissociation energy (ΔGdiss): 0.29 kcal/mol
Dissociation entropy (TΔSdiss): 8.66 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132597

Macromolecules

cAMP-dependent protein kinase catalytic subunit alpha
Chain: A
Length: 351 amino acids
Theoretical weight: 40.76 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00517 (Residues: 1-351; Coverage: 100%)
Gene name: PRKACA
Pfam: Protein kinase domain
InterPro:
CATH:
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 5vi9, assembly 1, front view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 5vi9, assembly 1, side view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 5vi9, assembly 1, top view.
Molecule details ›

Search similar proteins

cAMP-dependent protein kinase inhibitor alpha
Chain: B
Length: 18 amino acids
Theoretical weight: 1.97 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: Q3SX13 (Residues: 6-23; Coverage: 24%)
Gene name: PKIA
InterPro: cAMP-dependent protein kinase inhibitor
cAMP-dependent protein kinase inhibitor alpha in PDB entry 5vi9, assembly 1, front view.
cAMP-dependent protein kinase inhibitor alpha in PDB entry 5vi9, assembly 1, side view.
cAMP-dependent protein kinase inhibitor alpha in PDB entry 5vi9, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links