5vj6

Electron Microscopy
11.5Å resolution

BG505 SOSIP.664 in complex with broadly neutralizing antibodies PG9 and 8ANC195

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetradecamer (preferred)
PDBe Complex ID:
PDB-CPX-143685 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Transmembrane protein gp41 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 153 amino acids
Theoretical weight: 17.15 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 509-661; Coverage: 18%)
Gene name: env
Sequence domains: Retroviral envelope protein
Envelope glycoprotein gp160 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 481 amino acids
Theoretical weight: 54.06 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 30-505; Coverage: 55%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Immunoglobulin gamma-1 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 248 amino acids
Theoretical weight: 27.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DOX5 (Residues: 3-98, 99-107, 108-108, 109-224; Coverage: 49%)
Sequence domains:
Ig-like domain-containing protein Chains: M, O, Q
Molecule details ›
Chains: M, O, Q
Length: 233 amino acids
Theoretical weight: 24.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: S6B291 (Residues: 20-46, 47-90, 91-119, 120-125, 126-237; Coverage: 48%)
Sequence domains:
Ig-like domain-containing protein Chains: N, P, R
Molecule details ›
Chains: N, P, R
Length: 215 amino acids
Theoretical weight: 23.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8TCD0 (Residues: 21-239; Coverage: 98%)
Sequence domains:
Ig-like domain-containing protein Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 22.84 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6GMW3 (Residues: 22-43, 44-48, 49-234; Coverage: 97%)
Gene name: IGL@
Sequence domains:

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
Resolution: 11.5Å
Relevant EMDB volumes: EMD-8695
Expression system: Homo sapiens