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BG505 SOSIP.664 in complex with broadly neutralizing antibodies PG9 and 8ANC195

Electron Microscopy
11.5Å resolution
PDB entry 5vj6 coloured by chain, front view.
PDB entry 5vj6 coloured by chain, side view.
PDB entry 5vj6 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetradecamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetradecamer
Accessible surface area: 150062.38 Å2
Buried surface area: 43894.02 Å2
Dissociation area: 3,474.42 Å2
Dissociation energy (ΔGdiss): -32.27 kcal/mol
Dissociation entropy (TΔSdiss): 59.96 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-143685

Macromolecules

Transmembrane protein gp41
Chains: A, B, C
Length: 153 amino acids
Theoretical weight: 17.15 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 509-661; Coverage: 18%)
Gene name: env
Pfam: Retroviral envelope protein
InterPro: Retroviral envelope protein GP41-like
Transmembrane protein gp41 in PDB entry 5vj6, assembly 1, front view.
Transmembrane protein gp41 in PDB entry 5vj6, assembly 1, side view.
Transmembrane protein gp41 in PDB entry 5vj6, assembly 1, top view.
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Envelope glycoprotein gp160
Chains: D, E, F
Length: 481 amino acids
Theoretical weight: 54.06 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 30-505; Coverage: 55%)
Gene name: env
Pfam: Envelope glycoprotein GP120
InterPro:
Envelope glycoprotein gp160 in PDB entry 5vj6, assembly 1, front view.
Envelope glycoprotein gp160 in PDB entry 5vj6, assembly 1, side view.
Envelope glycoprotein gp160 in PDB entry 5vj6, assembly 1, top view.
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Immunoglobulin gamma-1 heavy chain
Chain: H
Length: 248 amino acids
Theoretical weight: 27.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DOX5 (Residues: 3-98, 99-107, 108-108, 109-224; Coverage: 49%)
Pfam:
InterPro:
Immunoglobulin gamma-1 heavy chain in PDB entry 5vj6, assembly 1, front view.
Immunoglobulin gamma-1 heavy chain in PDB entry 5vj6, assembly 1, side view.
Immunoglobulin gamma-1 heavy chain in PDB entry 5vj6, assembly 1, top view.
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Ig-like domain-containing protein
Chains: M, O, Q
Length: 233 amino acids
Theoretical weight: 24.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: S6B291 (Residues: 20-46, 47-90, 91-119, 120-125, 126-237; Coverage: 48%)
Pfam:
InterPro:
Ig-like domain-containing protein in PDB entry 5vj6, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 5vj6, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 5vj6, assembly 1, top view.
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Ig-like domain-containing protein
Chains: N, P, R
Length: 215 amino acids
Theoretical weight: 23.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8TCD0 (Residues: 21-239; Coverage: 98%)
Pfam:
InterPro:
Ig-like domain-containing protein in PDB entry 5vj6, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 5vj6, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 5vj6, assembly 1, top view.
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Ig-like domain-containing protein
Chain: L
Length: 216 amino acids
Theoretical weight: 22.84 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6GMW3 (Residues: 22-43, 44-48, 49-234; Coverage: 97%)
Gene name: IGL@
Pfam:
InterPro:
Ig-like domain-containing protein in PDB entry 5vj6, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 5vj6, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 5vj6, assembly 1, top view.
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