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Structure of human endothelial nitric oxide synthase heme domain in complex with 4-(2-(((2-Amino-4-methylquinolin-7-yl)methyl)amino)ethyl)-2-methylbenzonitrile

X-ray diffraction
2.4Å resolution
PDB entry 5vvc coloured by chain, front view.
PDB entry 5vvc coloured by chain, side view.
PDB entry 5vvc coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Nitric oxide synthase 3
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Multimeric state: homo dimer
Accessible surface area: 33483.37 Å2
Buried surface area: 11643.15 Å2
Dissociation area: 68.7 Å2
Dissociation energy (ΔGdiss): 40.72 kcal/mol
Dissociation entropy (TΔSdiss): -0.2 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-151512
Assembly 2 (preferred)
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Assembly Name: Nitric oxide synthase 3
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Multimeric state: homo dimer
Accessible surface area: 33281.03 Å2
Buried surface area: 11290.89 Å2
Dissociation area: 69.17 Å2
Dissociation energy (ΔGdiss): 40.73 kcal/mol
Dissociation entropy (TΔSdiss): -0.2 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-151512

Macromolecules

Nitric oxide synthase 3
Chains: A, B, C, D
Length: 440 amino acids
Theoretical weight: 49.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29474 (Residues: 41-480; Coverage: 37%)
Gene name: NOS3
Pfam: Nitric oxide synthase, oxygenase domain
InterPro:
CATH:
Nitric oxide synthase 3 in PDB entry 5vvc, assembly 2, front view.
Nitric oxide synthase 3 in PDB entry 5vvc, assembly 2, side view.
Nitric oxide synthase 3 in PDB entry 5vvc, assembly 2, top view.
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