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Crystal Structure of a Suz12-Rbbp4 Binary Complex

X-ray diffraction
3.2Å resolution
PDB entry 5wak coloured by chain, front view.
PDB entry 5wak coloured by chain, side view.
PDB entry 5wak coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histone-binding protein RBBP4 and Polycomb protein SUZ12
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Multimeric state: hetero dimer
Accessible surface area: 26003.47 Å2
Buried surface area: 9604.22 Å2
Dissociation area: 4,802.11 Å2
Dissociation energy (ΔGdiss): 59.22 kcal/mol
Dissociation entropy (TΔSdiss): 14.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-555237

Macromolecules

Histone-binding protein RBBP4
Chain: A
Length: 439 amino acids
Theoretical weight: 49.37 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q09028 (Residues: 1-425; Coverage: 100%)
Gene names: RBAP48, RBBP4
Pfam:
InterPro:
CATH: YVTN repeat-like/Quinoprotein amine dehydrogenase
Histone-binding protein RBBP4 in PDB entry 5wak, assembly 1, front view.
Histone-binding protein RBBP4 in PDB entry 5wak, assembly 1, side view.
Histone-binding protein RBBP4 in PDB entry 5wak, assembly 1, top view.
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Polycomb protein SUZ12
Chain: B
Length: 478 amino acids
Theoretical weight: 55.69 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15022 (Residues: 76-545; Coverage: 64%)
Gene names: CHET9, JJAZ1, KIAA0160, SUZ12
Polycomb protein SUZ12 in PDB entry 5wak, assembly 1, front view.
Polycomb protein SUZ12 in PDB entry 5wak, assembly 1, side view.
Polycomb protein SUZ12 in PDB entry 5wak, assembly 1, top view.
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