Structure analysis

US28 bound to engineered chemokine CX3CL1.35 and nanobodies

X-ray diffraction
3.5Å resolution
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 28784.59 Å2
Buried surface area: 6649.47 Å2
Dissociation area: 905.05 Å2
Dissociation energy (ΔGdiss): 2.67 kcal/mol
Dissociation entropy (TΔSdiss): 12.06 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-230970

Macromolecules

Chain: A
Length: 460 amino acids
Theoretical weight: 52.16 KDa
Source organism: Lama glama
Expression system: Homo sapiens
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Chain: B
Length: 76 amino acids
Theoretical weight: 8.63 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
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Chain: D
Length: 131 amino acids
Theoretical weight: 14.15 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
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