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Complex Structure of Staphylococcus aureus SdrE with human complement factor H

X-ray diffraction
3.3Å resolution
PDB entry 5wtb coloured by chain, front view.
PDB entry 5wtb coloured by chain, side view.
PDB entry 5wtb coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Complement factor H and Serine-aspartate repeat-containing protein E
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Multimeric state: hetero dimer
Accessible surface area: 15713.44 Å2
Buried surface area: 2241.95 Å2
Dissociation area: 1,120.97 Å2
Dissociation energy (ΔGdiss): 13.11 kcal/mol
Dissociation entropy (TΔSdiss): 9.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140217
Assembly 2
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Assembly Name: Complement factor H and Serine-aspartate repeat-containing protein E
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Multimeric state: hetero dimer
Accessible surface area: 15799.05 Å2
Buried surface area: 2229.62 Å2
Dissociation area: 1,114.81 Å2
Dissociation energy (ΔGdiss): 13.16 kcal/mol
Dissociation entropy (TΔSdiss): 9.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140217
Assembly 3
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Assembly Name: Complement factor H and Serine-aspartate repeat-containing protein E
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Multimeric state: hetero dimer
Accessible surface area: 15528.99 Å2
Buried surface area: 1715.75 Å2
Dissociation area: 857.87 Å2
Dissociation energy (ΔGdiss): 5.38 kcal/mol
Dissociation entropy (TΔSdiss): 8.77 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140217
Assembly 4
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Assembly Name: Complement factor H and Serine-aspartate repeat-containing protein E
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Multimeric state: hetero dimer
Accessible surface area: 15933.48 Å2
Buried surface area: 1717.17 Å2
Dissociation area: 858.58 Å2
Dissociation energy (ΔGdiss): 5.34 kcal/mol
Dissociation entropy (TΔSdiss): 8.78 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140217

Macromolecules

Serine-aspartate repeat-containing protein E
Chains: A, B, C, D
Length: 338 amino acids
Theoretical weight: 37.69 KDa
Source organism: Staphylococcus aureus subsp. aureus Mu50
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q932F7 (Residues: 270-599; Coverage: 30%)
Gene names: SAV0563, sdrE
Pfam:
InterPro:
CATH:
Serine-aspartate repeat-containing protein E in PDB entry 5wtb, assembly 1, front view.
Serine-aspartate repeat-containing protein E in PDB entry 5wtb, assembly 1, side view.
Serine-aspartate repeat-containing protein E in PDB entry 5wtb, assembly 1, top view.
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Complement factor H
Chains: E, F, G, H
Length: 21 amino acids
Theoretical weight: 2.51 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P08603 (Residues: 1206-1226; Coverage: 2%)
Gene names: CFH, HF, HF1, HF2
Pfam: Sushi repeat (SCR repeat)
Complement factor H in PDB entry 5wtb, assembly 1, front view.
Complement factor H in PDB entry 5wtb, assembly 1, side view.
Complement factor H in PDB entry 5wtb, assembly 1, top view.
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