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Plasmodium vivax SHMT(C346A) bound with PLP-glycine and MF011

X-ray diffraction
2.2Å resolution
PDB entry 5xmq coloured by chain, front view.
PDB entry 5xmq coloured by chain, side view.
PDB entry 5xmq coloured by chain, top view.
Source organism: Plasmodium vivax
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: glycine hydroxymethyltransferase
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Multimeric state: homo dimer
Accessible surface area: 29991.8 Å2
Buried surface area: 9642.94 Å2
Dissociation area: 4,821.47 Å2
Dissociation energy (ΔGdiss): 70.53 kcal/mol
Dissociation entropy (TΔSdiss): 14.57 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-107691
Assembly 2
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Assembly Name: glycine hydroxymethyltransferase
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Multimeric state: homo dimer
Accessible surface area: 29810.29 Å2
Buried surface area: 9758.8 Å2
Dissociation area: 4,879.4 Å2
Dissociation energy (ΔGdiss): 85.25 kcal/mol
Dissociation entropy (TΔSdiss): 13.75 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-107691

Macromolecules

glycine hydroxymethyltransferase
Chains: A, B, C
Length: 442 amino acids
Theoretical weight: 49.22 KDa
Source organism: Plasmodium vivax
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A5K8L9 (Residues: 1-442; Coverage: 100%)
Gene name: PVX_100730
Pfam: Serine hydroxymethyltransferase
InterPro:
CATH:
glycine hydroxymethyltransferase in PDB entry 5xmq, assembly 1, front view.
glycine hydroxymethyltransferase in PDB entry 5xmq, assembly 1, side view.
glycine hydroxymethyltransferase in PDB entry 5xmq, assembly 1, top view.
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