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Crystal structure of PD-L1 complexed with atezolizumab fab at 2.9A

X-ray diffraction
2.9Å resolution
PDB entry 5xxy coloured by chain, front view.
PDB entry 5xxy coloured by chain, side view.
PDB entry 5xxy coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Programmed cell death 1 ligand 1 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 22745.56 Å2
Buried surface area: 5255.79 Å2
Dissociation area: 1,030.2 Å2
Dissociation energy (ΔGdiss): -0.54 kcal/mol
Dissociation entropy (TΔSdiss): 11.89 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-212803

Macromolecules

heavy chain of atezolizumab fab
Chain: H
Length: 240 amino acids
Theoretical weight: 25.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
CATH: Immunoglobulins
heavy chain of atezolizumab fab in PDB entry 5xxy, assembly 1, front view.
heavy chain of atezolizumab fab in PDB entry 5xxy, assembly 1, side view.
heavy chain of atezolizumab fab in PDB entry 5xxy, assembly 1, top view.
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light chain of atezolizumab fab
Chain: L
Length: 214 amino acids
Theoretical weight: 23.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
CATH: Immunoglobulins
light chain of atezolizumab fab in PDB entry 5xxy, assembly 1, front view.
light chain of atezolizumab fab in PDB entry 5xxy, assembly 1, side view.
light chain of atezolizumab fab in PDB entry 5xxy, assembly 1, top view.
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Programmed cell death 1 ligand 1
Chain: A
Length: 124 amino acids
Theoretical weight: 14.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZQ7 (Residues: 18-133; Coverage: 42%)
Gene names: B7H1, CD274, PDCD1L1, PDCD1LG1, PDL1
Pfam: Immunoglobulin V-set domain
InterPro:
CATH: Immunoglobulins
Programmed cell death 1 ligand 1 in PDB entry 5xxy, assembly 1, front view.
Programmed cell death 1 ligand 1 in PDB entry 5xxy, assembly 1, side view.
Programmed cell death 1 ligand 1 in PDB entry 5xxy, assembly 1, top view.
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