Structure analysis

Crystal structure of a group 2 HA binding antibody AF4H1K1 Fab in complex with the 1968 H3N2 pandemic (H3-AC/68) hemagglutinin

X-ray diffraction
2.902Å resolution
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 41890.17 Å2
Buried surface area: 12706.17 Å2
Dissociation area: 1,794.57 Å2
Dissociation energy (ΔGdiss): 14.12 kcal/mol
Dissociation entropy (TΔSdiss): 13.98 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-208945

Macromolecules

Chain: A
Length: 329 amino acids
Theoretical weight: 36.22 KDa
Source organism: Influenza A virus (A/Aichi/2/1968(H3N2))
Expression system: Trichoplusia ni
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Chain: B
Length: 176 amino acids
Theoretical weight: 20.31 KDa
Source organism: Influenza A virus (A/Aichi/2/1968(H3N2))
Expression system: Trichoplusia ni
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Chain: I
Length: 233 amino acids
Theoretical weight: 24.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
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Chain: J
Length: 220 amino acids
Theoretical weight: 24.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
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